摘要
目的观察微波消融后的乳腺纤维腺瘤在兔活体内的转归。方法取长径1 cm的新鲜离体人乳腺纤维腺瘤标本,经微波消融灭活,移植于兔大腿肌肉层。采用体检、超声检查及病理检查连续观察微波消融后纤维腺瘤在兔体内的转归特点。结果实验兔均未出现操作相关的并发症。标本消融前的体积为(641.1±60.6)mm3,体检示标本完全吸收所需的时间为(11.6±1.5)周。超声检查示消融后标本起初表现为肌肉层内边界清晰的低回声团块,随时间延长,回声自周边增强,体积不断缩小,直至无法探及,时间为(14.0±3.1)周。病理学检查示微波消融后即刻乳腺纤维腺瘤的组织结构仍然完整,形态清晰可辨,随着在兔体内时间的延长,组织逐渐崩解、炎症细胞自周边向中心浸润。结论经微波消融后的乳腺纤维腺瘤可被吸收,不遗留瘢痕。超声检查可用于微波消融后的监测。
Objective We sought to evaluate the evolution of microwave ablated breast fibroadenomas in a nonviable transplantation model.Methods Breast fibroadenoma samples （1 cm） were ablated completely by microwave ablation （MWA） and implanted in the right hind limb of rabbits to simulate the in vivo environment.The clinical outcomes of resolved mass were evaluated via physical examination,ultrasound follow-up and histopathological examination.Results No local side effect and death related to the implantation were observed.Both physical examination and ultrasound follow-up provided information about the progressive absorption of ablated fibroadenomas.The mean volume pretreatment of fibroadenoma samples was （641.1 ± 60.6） mm3.Then,fibroadenoma samples became nonpalpable with an average duration of （11.6 ± 1.5） weeks.The ultrasound follow-up showed that the sample initially showed a hypoechoic mass with clear boundary within the muscle layer.As time went on,the echo enhanced from the periphery,and the volume decreased until it could not be detected with a mean time of （14.0 ± 3.1） weeks.Histopathological examination revealed an area of coagulation necrosis created by MWA and progressively eliminated from the body over time,and inflammatory cells infiltrated from the periphery to the center.Conclusions Since fibroadenomas treated by MWA can be resorbed smoothly over time without either colliquation or residual mass,MWA of breast fibroadenoma may have a promising cosmetic benefit.Ultrasound can be used effectively in monitoring the evolution of microwave ablated fibroadenoma.
出处
《中国肿瘤外科杂志》
CAS
2017年第5期300-304,共5页
Chinese Journal of Surgical Oncology
关键词
乳腺疾病
纤维腺瘤
微波
消融技术
兔
动物
实验
Breast diseases
Fibroadenoma
Microwaves
Ablation techniques
Rabbits
An-imals, laboratory
