摘要
转分化是指在特定条件下,一种细胞转变为另一谱系细胞类型的过程。近年来,转分化技术在干细胞和再生医学领域迅速发展,为神经系统疾病的治疗带来曙光。目前,转分化技术在神经系统疾病治疗中的研究已涵盖了神经退行性疾病、创伤性神经系统损伤以及神经精神障碍疾病等多个疾病多种神经元亚型。利用丰富且易于获取的体细胞转分化得到难以再生的功能性神经元是再生医学的新思路。本文着重对目前转分化在神经系统疾病中的研究进行综述。
Cell transdifferentiation is the direct conversion of one type of cell into another without becoming a pluripotent stem cell. Rapid progress in this field has brought new perspectives on understanding and treating disorders associated with the nervous system, such as neurodegeneration,traumatic injuries, and neuropsychiatric diseases. Being able to obtain functional neurons through transdifferentiation from abundant somatic cells also provides a new strategy for regenerative medicine. In this review we highlight the recent progress in cell transdifferentiation for neurological disorders and discuss potential challenges facing its clinical applications.
作者
裴春丽
王树坤
张春立
PEI Chun-li;WANG Shu-kun;ZHANG Chun-li(State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;Instiute of Military Cognitive and Brain Sciences, Academy of Mililtary Medical Sciences, Beijing 100850, China;Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA)
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
2017年第11期1106-1113,共8页
Chinese Journal of Pharmacology and Toxicology
基金
国家自然科学基金(81528006)
国家自然科学基金(31600946)~~
关键词
转分化
神经退行性疾病
创伤性神经系统损伤
神经精神障碍
transdifferentiation
neurological disorders
neurodegeneration
traumatic nervous system injury
neuropsychiatric diseases
