摘要
目的探讨非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)患者肾脏功能状况,并对相关因素进行分析.方法本研究共纳入856例健康查体者,将其中诊断NAFLD患者的生化学指标与对照组人群进行统计学分析;利用估算的肾小球率过滤(estimated glomerular rate filtration,eG FR)对两组人群肾脏功能进行评价;筛选肾脏损害的影响因素.结果筛选出符合NAFLD诊断的患者253例,对照人群603例,两组比较发现血清尿素氮(BUN)t=1.678,P值为0.062,差异无统计学意义,其他生化学指标P<0.05,差异均有统计学意义;检出的肾脏功能受损(e GFR<90m L/m i n·1.73 m2)患者中,伴N A F L D的患病率高于不伴NAFLD的患者(28.8%和17.5%,P<0.0001).进一步用Logistic回归分析发现肾脏功能受损与是否NAFLD经调整人口学资料及代谢综合征指标后仍显示相关(OR=2.85,95%CI:1.93-4.21,P=0.000).结论 NAFLD患者生化学指标与对照人群比较显示明显差异,肾脏功能受损与NAFLD具有关联性,NAFLD患者应定期进行肾功能评估以避免进展为慢性肾脏疾病而增加远期医疗负担.
AIM To assess the renal function in patients with nonalcoholic fatty liver disease （NAFLD） and to identify the riskfactors for renal dysfunction.METHODS A total of 856 volunteers who underwent health examination were initially enrolled in this study to identify those with NAFLD. The biochemical indexes of patients with NAFLD and healthy volunteers were statistically analyzed, and the renal function with estimated glomerular filtration rate was calculated. In addition, the risk factors for renal damage were identified. RESULTS A total of 253 patients with NAFLD were identified, and the remaining 603 cases were used as a control group. There was no significant difference in serum BUN between the two groups （t = 1.678, P = 0.062）, while other biochemical indexes differed significantly （P 〈 0.05）. The prevalence of renal function impairment was higher in individuals with NAFLD compared to those without （28.8% vs 17.5%, P 〈 0.0001）. Logistic regression analysis showed that NAFLD was associated with renal function impairment, even after adjustment for demographics and components of metabolic syndrome （OR = 2.85, 95%CI： 1.93-4.21, P = 0.000）. The biochemical indexes of NAFLD patients are significantly abnormal, and renal function impairment is associated with NAFLD. Patients with NAFLD should be regularly assessed for renal function to avoid progressing into chronic kidney disease and increasing the medical burden.
作者
马艳红
Yan-Hong Ma(Department of Infectious Diseases, Binhai Hospital of Tianjin Medical University General Hospital, Tianjin 300480, Chin)
出处
《世界华人消化杂志》
CAS
2018年第11期667-672,共6页
World Chinese Journal of Digestology
关键词
非酒精性脂肪性肝病
慢性肾脏疾病
肾小球率过滤
肾脏功能受损
Nonalcoholic fatty liver disease
Chronic kidneydisease
GIomerular filtration rate
Renal function impairment
