摘要
目的探讨高分级动脉瘤性蛛网膜下腔出血患者血浆miRNA155水平预测神经源性肺水肿的发生。方法选取高分级动脉瘤性蛛网膜下腔出血患者30例,其中蛛网膜下腔出血后发生神经源性肺水肿患者11例,蛛网膜下腔出血后未发生神经源性肺水肿患者19例,同时选取同期体检者20例作为对照组,检测3组血浆miRNA155水平。结果发生神经源性肺水肿与未发生神经源性肺水肿的高分级蛛网膜下腔出血患者血浆miRNA155水平高于对照组,发生神经源性肺水肿的高分级蛛网膜下腔出血患者血浆miRNA155水平高于未发生神经源性肺水肿的高分级蛛网膜下腔出血患者,其组间、组间·时点间交互作用差异有统计学意义(P<0.05)。结论发生神经源性肺水肿的蛛网膜下腔出血患者血浆miRNA水平明显增高,可预测高分级蛛网膜下腔出血后神经源性肺水肿的发生。
Objective To investigate the plasma miRNA155 level in patients with poorgrade aneurysmal subarachnoid hemorrhage（SAH）and predict the occurrence of neurogenic pulmonary edema（NPE）.Methods Thirty patients with high grade aneurysmal subarachnoid hemorrhage were selected,including 11 cases of neurogenic pulmonary edema after subarachnoid hemorrhage,19 cases of subarachnoid hemorrhage without neurogenic pulmonary edema,and 20 cases of physical examinees at the same time as a control group,and the levels of plasma miRNA155 were detected in 3 groups.Results The level of plasma miRNA155 in patients with poor-grade subarachnoid hemorrhage with neurogenic pulmonary edema and non neurogenic pulmonary edema was higher than that in the control group.The level of plasma miRNA155 in patients with high grade subarachnoid hemorrhage with neurogenic pulmonary edema was higher than that of high grade subarachnoid hemorrhage without neurogenic pulmonary edema.There was a significant difference in the interaction between patients and between groups（P〈0.05）.Conclusion Plasma miRNA level is significantly higher in patients with subarachnoid hemorrhage with neurogenic pulmonary edema.Elevated miRNA can predict the occurrence of neurogenic pulmonary edema after poor-grade subarachnoid hemorrhage.
作者
杨磊
张栋梁
韩永丰
李聪慧
宋贺
张世阳
YANG Lei;ZHANG Dong-liang;HAN Yong-feng;LI Cong-hui;SONG He;ZHANG Shi-yang(The Third Department of Neurosurgery, the First Hospital of Shijiazhuang, Hebei Province,Shijiazhuang050011, China;The Third Department of Intensive Medicine, the First Hospital of Shijiazhuang,Hebei Province, Shijiazhuang 050011, China;The Third Department of Geriatrics, the FirstHospital of Shijiazhuang, Hebei Province, Shijiazhuang 050011, China)
出处
《河北医科大学学报》
CAS
2018年第5期543-546,551,共5页
Journal of Hebei Medical University
基金
河北省科技计划项目(162777208)
关键词
蛛网膜下腔出血
肺水肿
微RNA
subarachnoid hemorrhage
pulmonary edema
microRNAs
