摘要
目的分析开滦健康体检人群贫血患病率及其随时间变化的趋势及影响贫血的因素。方法对参加2006、2008、2010、2012、2014年度5次健康体检的开滦在职及退休职工进行统一问卷调查、血液常规和生化检查。男性血红蛋白（Hb）〈120 g/L和女性〈110 g/L定义为贫血。计算贫血患病率，分析贫血患病率随时间变化的趋势，采用多因素logistics回归分析贫血的影响因素结果（1）2006—2014年5次健康体检人群的贫血患病率分别是3.7%、3.1%、2.4%、1.3%、1.5%；按性别分层：男性贫血患病率分别是3.3%、2.3%、1.9%、0.8%、1.0%，女性贫血患病率分别是5.3%、5.9%、4.2%、3.1%、3.3%。各年份女性贫血患病率均高于男性（P〈0.05）。2006—2014年随着时间的推移，总人群贫血患病率及男性、女性贫血患病率均呈下降趋势（趋势χ2检验，P〈0.05）。（2）多因素logistic回归分析显示：增龄、超敏C反应蛋白（hs-CRP）升高与贫血呈正相关，其OR值分别为1.01（95%CI 1.01~1.02）、1.03（95%CI 1.02~1.03）；贫血的负相关因素为男性、BMI、体育锻炼、吸烟、高脂血症病史，其OR值分别为0.60（95%CI 0.55~0.65）、0.99（95%CI 0.98~0.99）、0.91（95%CI 0.82~0.98）、0.87（95%CI 0.81~0.95）、0.87（95%CI 0.81~0.94）。结论开滦健康体检人群贫血患病率在男性和女性中存在差异，女性高于男性。随着时间的推移，贫血患病率水平有所下降。增龄、hs-CRP升高与贫血呈正相关，男性、BMI升高、加强体育锻炼、吸烟、存在高脂血症病史与贫血呈负相关。
ObjectiveTo analyze the prevalence and risk factors of anemia in a general population in Kailuan.MethodsWorking and retired employees in Kailuan Company who had participated in biennial physical examination from 2006-2014 were investigated by questionnaire and blood test. Hemoglobin levels〈120 g/L in male and〈110 g/L in female are defined as anemia. The trend of prevalence of anemia was analyzed by chi square test. Multivariable logistic regression was used to analyze the factors associated with anemia.Results（1） The biennial prevalence of anemia in Kailuan during 2006-2014 were 3.7%, 3.1%, 2.4%, 1.3%, 1.5%. The corresponding proportion were 3.3%, 2.3%, 1.9%, 0.8%, 1.0% in males and 5.3%, 5.9%, 4.2%, 3.1% and 3.3% in females, respectively. The differences between males and females were statistically significant （all P〈0.05）. The prevalence of anemia declined over time （P for trend〈0.05）. （2） The results of multivariable logistic regression showed that aging and elevated hs-CRP were positively associated with anemia, with OR= 1.01 （95%CI 1.01-1.02） and 1.03 （95%CI 1.02-1.03） , respectively. While male, BMI, physical exercise, smoking, hyperlipidemia were negatively associated with anemia with OR= 0.60 （95%CI 0.55-0.65） , 0.99 （95%CI 0.98-0.99） , 0.91 （95%CI 0.82-0.98） , 0.87 （95%CI 0.81-0.95） and 0.87 （95%CI 0.81-0.94） , respectively.ConclusionsThe prevalence of anemia in a large general population in Kailuan has been analyzed. Prevalence of anemia is higher in males than females and declines over time. Several demographic and clinical characteristics are associated with anemia.
作者
李君
李志芳
侯金友
卢焱坤
张晓磊
张秀梅
邹红蕊
张慧
崔妍
谢怡华
鲁弼嘉
张鹏
王晋伟
张路霞
Li Jun;Li Zhifang;Hou Jinyou;Lu Yankun;Zhang Xiaolei;Zhang Xiumei;Zou Hongrui;Zhang Hui;Cui Yan;Xie Yihua;Lu Bijia;Zhang Peng;Wang Jinwei;Zhang Luxia(Renal Division, Peking University Institiute of Nephrology, Peking University First Hospital, Beijing 100034, China)
出处
《中华内科杂志》
CAS
CSCD
北大核心
2018年第5期335-339,共5页
Chinese Journal of Internal Medicine
基金
十三五国家重点研发计划项目（2016YFC1305400）
仁泽公益基金
关键词
贫血
患病率
流行病学
影响因素
Anemia
Prevalence
Epidemiology
Influence factors
