摘要
目的分析支气管肺癌患者外周血T淋巴细胞亚群表达情况及其与预后的关系。方法选取2015年8月—2017年8月哈尔滨医科大学附属第四医院松北医院和哈尔滨医科大学附属第一医院收治的支气管肺癌患者60例作为支气管肺癌组,按照预后分为预后良好组31例与预后不良组29例;另选取同期于哈尔滨医科大学附属第四医院松北医院和哈尔滨医科大学附属第一医院体检健康者60例作为对照组。比较对照组、观察组受试者外周血T淋巴细胞亚群表达情况,支气管肺癌患者预后的影响因素分析采用多因素Logistic回归分析。结果支气管肺癌组患者外周血CD_3^+细胞分数、CD_4^+细胞分数、CD_4^+/CD_8^+细胞比值低于对照组(P<0.05);两组受试者外周血CD_8^+细胞分数比较,差异无统计学意义(P>0.05)。预后良好组与预后不良组患者性别、年龄、临床分期、病理类型比较,差异无统计学意义(P>0.05);两组患者肿瘤直径、肿瘤分化程度及外周血CD_3^+细胞分数、CD_4^+细胞分数、CD_8^+细胞分数、CD_4^+/CD_8^+细胞比值比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,肿瘤分化程度[OR=3.425,95%CI(1.307,9.036)]及外周血CD_3^+细胞分数[OR=0.431,95%CI(0.301,0.617)]、CD_4^+细胞分数[OR=0.269,95%CI(0.129,0.562)]、CD_8^+细胞分数[OR=2.740,95%CI(1.528,4.914)]、CD_4^+/CD_8^+细胞比值[OR=0.291,95%CI(0.150,0.565)]是支气管肺癌患者预后的影响因素(P<0.05)。结论支气管肺癌患者外周血T淋巴细胞亚群呈低表达,肿瘤分化程度及外周血CD_3^+细胞分数、CD_4^+细胞分数、CD_8^+细胞分数、CD_4^+/CD_8^+细胞比值是支气管肺癌患者预后的影响因素。
Objective To analyze the peripheral blood T-lymphocyte subsets expression and its relation with prognosis in patients with bronchopulmonary carcinoma. Methods From August 2015 to August 2017, a total of 60 patients with bronchopulmonary carcinoma were selected as case group in Songbei Hospital of the Fourth Hospital Affiliated to Harbin Medical University and the First Hospital Affiliated to Harbin Medical University, and they were divided into A group（with good prognosis, n=31） and B group（with poor prognosis, n=29） according to the prognosis; meanwhile a total of 60 healthy volunteers were selected as control group. Peripheral blood T-lymphocyte subsets expression was compared between control group and case group, and influencing factors of prognosis in patients with bronchopulmonary carcinoma were analyzed by multivariate Logistic regression analysis. Results Peripheral blood CD3＋ cell percentage, CD4＋ cell percentage and CD4＋/CD8＋ cell ratio in case group were statistically significantly lower than those in control group（P〈0.05）, while no statistically significant differences of peripheral blood CD8＋ cell percentage was found between the two groups（P〉0.05）. No statistically significant differences of gender, age, clinical stages or pathological types was found between A group and B group（P〉0.05）, while there were statistically significant differences of diameter and differentiation level of tumor, peripheral blood CD3＋ cell percentage, CD4＋ cell percentage, CD8＋ cell percentage and CD4＋/CD8＋ cell ratio between the two groups（P〈0.05）. Multivariate Logistic regression analysis results showed that, differentiation level of tumor[OR=3.425, 95%CI（1.307, 9.036）],peripheral blood CD3＋ cell percentage[OR=0.431, 95%CI（0.301, 0.617）], CD4＋ cell percentage[OR=0.269, 95%CI（0.129, 0.562）], CD8＋ cell percentage[OR=2.740, 95%CI（1.528, 4.914）] and CD4＋/CD8＋ cell ratio[OR=0.291, 95%CI（0.150, 0.565）] were influencing factors of prognosis in patie
作者
陶辰楠
李世敏
关丽娜
TAO Chen-nan;LI Shi-min;GUAN Li-na(The Third Department of Comprehensive Internal Medicine, Songbei Hospital of the Fourth Hospital Affiliated to Harbin Medical University, Harbin 150000, China;The First Hospital Affiliated to Harbin Medical University, Harbin 150000, China)
出处
《实用心脑肺血管病杂志》
2018年第3期37-40,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
