摘要
结直肠癌在我国有很高的发病率和死亡率,T调节淋巴细胞是抗肿瘤免疫的关键一环。然而不同于其他实体肿瘤的研究结论,目前对于T调节淋巴细胞在结直肠癌中的意义,包括其在结直肠癌发生发展不同阶段的作用,在肿瘤组织内的不同部位、肿瘤组织与外周血、肿瘤不同区域引流淋巴结中的存在状态及对患者预后的影响等均存在不一致结论。临床上,针对PD-1/PDL-1和CTLA-4靶点免疫治疗的成功为以T调节淋巴细胞为着眼点的抗肿瘤研究提供了新方法,结合T调节淋巴细胞在结肠癌中的相关研究结论,未来在此领域仍有很大的探索空间。
Colorectal cancer is marked by its high morbidity and mortality in our country,the T regulatory cells are of the key components of immunotherapy in cancers. However,inconsistent with previous established conclusions in other solid cancers,the significance of T regulatory cells in colorectal cancer,which including its role in different stages of cancer,its distribution in different area in tumor mass,its variance in tumor and peripheral blood as well as its appearance in varied regional drainage lymph nodes,is still largely under debate. Currently,the success of targeting PD-1/PDL-1 and CTLA-4 in clinic opened a new era of immunotherapy for cancer patients which focused on T regulatory cells,taking into consideration of the uncertain conclusions about Treg in colorectal cancer,additional studies are still needed in future.
作者
颜兵
刘辉
游俊浩
李方
Yan Bing;Liu Hui;You Junhao;Li Fang(Department of Oncology , Hainan Branch of PLA General Hospital, Sanya 572000, Hainan, Chin)
出处
《肿瘤预防与治疗》
2018年第2期155-159,共5页
Journal of Cancer Control And Treatment
基金
国家自然科学基金青年基金(编号:81503391)
海南省自然科学基金面上项目(编号:817352)
三亚市医疗卫生科技创新项目(编号:2016YW08)
