摘要
目的探讨丝裂霉素C在翼状胬肉切除术后对泪膜稳定性的影响。方法选取2016年1月~2017年5月九江市第一人民医院收治的86例原发性翼状胬肉患者(138眼),随机分为翼状胬肉切除伴羊膜移植组(A组),翼状胬肉切除伴羊膜移植联合应用丝裂霉素C(MMC)组(B组)。术前及术后1个月、3个月行泪液分泌试验(SIt)、泪膜破裂时间(BUT)、角膜荧光素染色(CFS)检查。结果术后1个月,两组的CFS、BUT与术前比较,差异有统计学意义(P<0.05),两组间比较,差异有统计学意义(P<0.05);术后1个月,两组的SIt较术前及组间比较差异均无统计学意义(P>0.05);术后3个月,两组的CFS、BUT、SIt较术前及组间比较差异均无统计学意义(P>0.05)。结论胬肉切除术后早期对泪膜功能有影响,术后3个月泪膜功能基本恢复正常;翼状胬肉切除伴羊膜移植术后早期对泪膜功能影响小于翼状胬肉切除伴羊膜移植联合应用MMC。
Objective To investigate the influence of Mitomycin C the stability of tear film after pterygium surgery.Methods A total of 86（138 eyes） patients with primary pterygium admitted into our hospital from January 2016 to May2017 were selected,and randomly divided into pterygium excision with amniotic membrane transplantation（group A）and pterygium excision combined with amniotic membrane transplantation and mitomycin C（MMC） group（group B）.The tear secretion test（Schirmer I）,break-up time（BUT） of the tear film and corneal fluorescein staining（CFS） examination were performed before surgery,1 and 3 months after surgery.Results One month after operation,the CFS and BUT of the two groups were significantly different from those before operation（P〈0.05）.There were significant differences in the two indicators after inter-group comparison（P〈0.05）.One month after surgery,there was no significant difference in SIt before surgery or after inter-group comparison（P〉0.05）.Three months after operation,no great difference was displayed in CFS,BUT,or SIt compared with prior surgery or between the two groups（P〉 0.05）.Conclusion pterygium resection in early stage has some influence on the function of tear film.Three months after surgery,the function of tear film becomes basically normal.Compared with pterygium excision combined with amniotic membrane transplantation and MMC,the impact on the function of tear film by pterygium excision and amniotic membrane transplantation at early stage is milder.
作者
江会丰
欧阳君
JIANG Hui-feng;OUYANG Jun(Department of Ophthalmology,No.1 People＇s Hospital of Jiujiang City in Jiangxi Provinee,Jiujiang 332000,China)
出处
《中国当代医药》
2018年第11期105-107,共3页
China Modern Medicine
关键词
翼状胬肉
羊膜移植
翼状胬肉切除
丝裂霉素C
泪膜
Pterygium
Amniotic membrane transplantation
Pterygium excision
Mitomycin C
Tear film
