摘要
目的:观察急性脑梗死合并H型高血压患者血清UA(尿酸)、Hcy(同型半胱氨酸)、胱抑素C水平与颈动脉内中膜厚度(IMT)的相关性。方法:选取临床明确诊断的急性脑梗死合并H型高血压的患者200例,根据IMT水平分成3组:IMT正常组(54例)、IMT增厚组(63例)、斑块形成组(83例);比较3组间年龄、性别、体质指数、生化指标水平,分析其与IMT的相关性,同时采用Logistic回归分析影响颈动脉粥样硬化的因素。结果:(1)与IMT正常组比较,IMT增厚组、斑块形成组在收缩压(SBP)、舒张压(DBP)、甘油三酯(TG)、低密度脂蛋白(LDLC)、脂蛋白a、UA、胱抑素C、Hcy等方面均明显升高,差异有统计学意义(均P<0.01或P<0.05);(2)Pearson相关分析,结果显示:IMT与SBP、DBP、TG、LDLC、脂蛋白a、UA、胱抑素C、Hcy、年龄均呈明显正相关(均P<0.01或P<0.05);(3)Logistic回归分析,结果显示:SBP、TG、LDLC、脂蛋白a、UA、胱抑素C、Hcy为颈动脉粥样硬化的危险因素(均P<0.01或P<0.05)。结论:急性脑梗死合并H型高血压患者血清SBP、DBP、TG、LDLC、脂蛋白a、UA、胱抑素C、Hcy与IMT呈正相关,是导致颈动脉粥样硬化的独立危险因素。
Objective：To observe the levels of plasma homocysteine（Hcy ） , Uric acid（UA ） , Cystatin C （Cyst-C） in pa-tients with acute cerebral infarc t ion complicated wi th H type hypertension , and analysis correlation between He y , UA , Cytt-C and the carotid artery intima-media thickness （IMT ）. Methods ： There were 200 patients w i th acute cerebral in -farction complicated wi th H type hypertension were selected fo r the study. T hey were divided into intima-media thickness group（54 cases） ？ carotid artery intima-media thickness thickening g ro u p（63 cases） and carotid artery plaque group（83 cases） according to the difference of carotid a rtery intima-media thickness. T he age, gender,Body mass index（BMI） , the levels o f plasma Hc y ,UA ,Cyst-C and biochemical indicator among the three groups are de-tected and compared,and their correlation wi th carotid artery intima-media thickness was analyzed. T he influencing fac-tors of carotid atherosclerosis were analyzed by Log is t ic regression analysis. Results： （1） Comparerotid artery intima-media thickness g ro u p,the levels of Systolic pressure（S B P ）,Diastolic pressure（D B P ）,triglycerides （TG）,Lowdensity l ipoprotein （LDLC）,L ip o p ro te in a, H e y, UA , Cyst-C in the carotid artery intima-media thickness thickening group and the carotid a rtery plaque group were signif icant ly increased（P 〈0. 05 or P〈0. 01）. （2）C a ro t id ar-tery intima-media thickness was positively correlated wi th the SBP , DBP , T G , LD LC , L ip o p ro te in a , Hey , U A , Cyst-C and age （P 〈0. 05 or P 〈0. 01）. （3） Log is t ic regression analysis showed th a t the levels of SBP , DBP , T G LD LC , L ip o -protein a , Hey , UA , Cyst-C were the independent r is k factors fo r the development of carotid or P 〈0. 01）. Conclusion：The levels o f SBP, D B
作者
伍能生
邓桂辉
李青
WU Nengsheng;DENG Guihui;LI Qing.(Department of Neurology,Haicang Hospital,Xiamen City,Fujian Province 361000)
出处
《医学理论与实践》
2018年第8期1107-1109,共3页
The Journal of Medical Theory and Practice
关键词
急性脑梗死
H型高血压
颈动脉内中膜厚度
血尿酸
相关性
Acute cerebral infarction , H type hypertension , Carotid artery intima-media thickness , Uric acid , Correlation
