摘要
目的探讨联合检测血清同型半胱氨酸和胱抑素C与肺癌化疗的相关性。方法选取本院2016年1月-12月的85例肺癌患者作为试验组,并选取85例正常人作为对照组,分别检测试验组患者化疗前、后及对照组的血清同型半胱氨酸及胱抑素C水平。结果试验组的血清同型半胱氨酸与胱抑素C水平明显高于对照组;试验组化疗后的血清同型半胱氨酸与胱抑素C水平明显低于化疗前;血清同型半胱氨酸、胱抑素C水平与肺癌的分期恶化程度呈正相关;血清同型半胱氨酸与胱抑素C联合检测肺癌的灵敏性明显高于单个检测的灵敏性,上述差异均有统计学意义(P<0.05)。结论血清同型半胱氨酸与胱抑素C联合检测具有较高的灵敏性和特异性,并在肺癌化疗前后有明显变化,与肺癌的疗效有关。
Objective To study the correlation of serum homocysteine and cystatin C detection with chemotherapy in lung cancer. Methods From January to December in 2016, 85 cases of lung cancer patients in our hospital were collected as the experimental group, and 85 cases of normal people were enrolled as control group. The levels of homocysteine and cystatln C before and after chemotherapy in the test group and the control group were measured. Results Levels of homocysteine and cystatin C in experimental group were significantly higher than that in the control group ; levels of homocysteine and cystatin C after chemotherapy were significantly lower than that before chemotherapy; homoeysteine and cystatin C had a positive correlation with the deterioration of lung cancer; the sensitivity of the combined detection of serum homocysteine and cystatin C in lung cancer was significantly higher than that of the single detection, with the differences all statistically significant （ P 〈 0.05 ）. Conclusion The combined detection of serum homocysteine and cystatin C has high sensitivity and specificity, and has obvious changes before and after lung cancer chemotherapy, which is related to the curative effect of lung cancer.
作者
丁运生
李跃
姚余友
DING Yun sheng;LI Yue;YAO Yu＇ you(School of Public Health, Anhui Medical University, Hefei, Anhui 230032, Chin)
出处
《中国卫生检验杂志》
CAS
2018年第8期964-966,共3页
Chinese Journal of Health Laboratory Technology
关键词
肺癌
同型半胱氨酸
胱抑素C
化疗
Lung cancer
Homocysteine
Cystatin C
Chemotherapy
