摘要
目的探究高胆红素血症新生儿血清胆红素的变化与继发性血小板增多症和凝血功能异常的关系。方法选取2016年6月~2017年6月于我院新生儿科住院的35例高胆红素血症患儿作为观察组,另取同期35例血清胆红素正常的新生儿作为对照组,比较两组新生儿外周血PLT、APTT、PT、TT、Fib水平以及继发性血小板增多症发生率。根据患儿血清总胆红素(TBiL)水平分为<257μmol/L组和>257μmol/L组,对比二组患儿PLT、APTT、PT、TT、Fib水平以及继发性血小板增多症发生率。观察血小板增多症患儿与PLT正常患儿TBiL恢复正常的时间。结果 1.观察组患儿外周血PLT、APTT、PT、TT水平高于对照组,Fib低于对照组,差异有统计学意义(t=8.14、7.33、7.54、4.64和5.18,均P<0.05);观察组与对照组患儿继发性血小板增多症发病率分别为19.9%和5.9%,差异有统计学意义(χ2=6.94,P<0.05);2.>257μmol/L组PLT、APTT、PT、TT和FIB与<257μmol/L组均具有显著的差异(t=2.56、2.71、2.11、2.23和2.45,P<0.05)存在显著差异。而继发性血小板增多症发病率在两组之间不存在显著的统计学差异(χ2=2.58,P>0.05);3.血小板增多症患儿外周血TBiL恢复正常时间为(10.2±3.4)d,PLT正常患儿外周血TBiL恢复正常时间为(8.3±1.5)d,两组差异有统计学意义(t=6.46,P<0.05)。结论新生儿高胆红素血症可引起PLT增多和凝血功能异常;2.随着血清TBiL水平升高,凝血功能受损加重;3.继发性血小板增多症可延长患儿血清TBiL恢复正常时间。
Objective：To investigate the relationship between serum bilirubin levels and secondary thrombocytosis and abnormal coagulation function in neonates with hyperbilirubinemia. Methods：From June 2016 to June 2017,35 cases of hyperbilirubinemia in newborn Department of Pediatrics in our hospital as the observation group,another 35 cases of normal serum bilirubin in newborns during the same period as the control group,serum PLT and neonatal were compared between the two groups APTT,PT,TT,Fib levels and the incidence of secondary thrombocytosis. According to the serum total bilirubin（TBiL）level,the patients were divided into〈257 μmol/L group and〉257 μmol/L group,and the levels of PLT,APTT,PT,TT,Fib and secondary thrombocytosis in two groups were compared. To observe the normal recovery time of TBiL in children with thrombocytosis and normal PLT. Results：The serum PLT,1. patients in the observation group APTT,PT,TT levels higher than the control group,Fib was lower than the control group,the difference was statistically significant（t=8.14,7.33,7.54,4.64 and 5.18,P〈0.05）;the observation group and the control group of children with secondary thrombocytosis incidence rates were 19.9% and 5.9%,the difference was statistically significant（2=6.94,P〈0.05）;2.〉257 mol/L PLT,APTT,PT group,TT and FIB and〈257 in mol/L group were significantly different（t=2.56,2.71,2.11,2.23 and 2.45,P〈0.05）there are significant differences. While the secondary thrombocytosis incidence there is no statistically significant difference between the two groups（2=2.58,P〉0.05）;3. thrombocytosis in peripheral blood of children with normal time for TBiL（10.2±3.4）d,PLT in peripheral blood of children with normal recovery time of TBiL for D（8.3±1.5）,the two groups had statistical significance the difference（t=6.46,P〈0.05）. Conclusion：1. neonatal hyperbilirubinemia can cause the increase of PLT and abnormal blood coagulation;2. with elevated serum TBiL levels and coagulation function injury;3. second
作者
王军梅
毛桂平
赵海举
WANG Jun-mei;MAO Gui-ping;Zhao Hai-ju(Laborawry of Xiangyang City Center Hospital, Affiliated Hospital of Hubei College of Arts and Sciences, Xiangyang, Hubei, 441021)
出处
《中国优生与遗传杂志》
2018年第4期61-63,共3页
Chinese Journal of Birth Health & Heredity
