摘要
目的:观察辨证运用通法联合甲钴胺治疗气虚血瘀型糖尿病神经病变(diabetic peripheral neuropathy,DPN)的临床疗效。方法:选择2015-01~2017-01我科门诊及住院诊断为气虚血瘀型DPN的患者80例,随机分为中西医结合组及西医组,每组各40例。所有患者口服降糖药及胰岛素治疗,西医组给予甲钴胺胶囊口服治疗,中西医结合组在此基础上,给予补阳还五汤加减口服,观察两组疗效。结果:治疗3个疗程后,根据西医疗效评价标准,西医组有效率为62.5%,中西医结合组有效率为85.0%;根据中医疗效评价标准,西医组有效率为62.0%,中西医结合组有效率为90.0%,两组比较差异均具有统计学意义(P<0.05或P<0.01)。中西医结合组患者治疗后正中神经、腓总神经感觉神经传导速度(SCV)和运动神经传导速度(MCV)显著提高,效果优于西医组(P<0.01);神经症状、神经反射及感觉实验改善情况显著优于西医组(P<0.01);中医临床症状评分改善情况明显优于西医组(P<0.01)。结论:辨证运用通法结合西药治疗气虚血瘀型DPN效果明显优于单用西药,值得临床推广。
Objective：To observe the clinical effect of Tong method combined with Mecobalamin in the treatment of diabetic peripheral neuropathy（DPN）with qi deficiency and blood stasis type.Methods：Eighty patients with DPN diagnosed as qideficiency and blood stasis type from January 2015 to January 2017 were randomly divided into integrative medicine group and western medicine group,40 cases in each group.All patients were treated with oral hypoglycemic agents and insulin therapy.Western medicine group were given mecobalamin capsules orally.Integrative medicine group were treated with Buyanghuanwu decoction orally on the basis of treayment for western medicine group.The efficacy in the two groups were observed.Results：After treatment,the efficacy rate in western medicine group was 62.5%,while in integrative medicine group was 85.0% according to western medicine efficacy standard.The efficacy rate in western medicine group was 62.0%,while in integrative medicine group was 90.0% according to traditional Chinese medicine efficacy standard.The differences between the two groups were statistically significant（P〈0.05 or P〈0.01）.The SCV and MCV of the median nerve,common peroneal nerve of the patients in integrative medicine group improved significantly,and the improvement of neurological symptoms,reflex and sensory test and clinical symptom in integrative medicine group was significantly better than those in western medicine group（P〈0.01）.Conclusion：Tong method combined with Mecobalamin in the treatment of DPN with qi deficiency and blood stasis syndrome is obviously superior to single western medicine,which is worthy of clinical promotion.
作者
马迪
张芸
陈岳祺
颜洁
MA Di;ZHANG Yun;CHEN Yueqi;YAN Jie(Department of Endocrinology, Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming 650021,China)
出处
《西北国防医学杂志》
CAS
2018年第3期183-187,共5页
Medical Journal of National Defending Forces in Northwest China
关键词
糖尿病神经病变
通法
甲钴胺
气虚血瘀
diabetic peripheral neuropathy, Tong method, Mecobalamin, qi deficiencyand blood stasis
