摘要
目的:分析肠球菌医院感染的特征及其对新型抗菌药物的耐药性。方法:抽取2016年2月—2017年6月间临床送检标本中检出医院感染的肠球菌属细菌160株资料,统计这些菌株的细菌分离培养、鉴定以及药敏试验结果,分析肠球菌医院感染的特征以及对抗菌药物的耐药性。结果:160株肠球菌中,尿液标本检出率为最高(58.13%),其中以粪肠球菌(55.00%)与屎肠球菌(37.50%)为主;屎肠球菌对青霉素、红霉素、利福平、氨苄西林、环丙沙星和左氧氟沙星的耐药率均大于75.00%,粪肠球菌除对红霉素、四环素、利福平外的耐药率均低于25.00%(P<0.05);粪肠球菌与屎肠球菌对万古霉素的耐药率为0,而对利奈唑胺的耐药率前者为1.14%,后者为0;两种菌株对高浓度庆大霉素与高浓度链霉素的耐药率均大于40.00%(P>0.05);在四环素和喹奴普丁/达福普丁的耐药率观察,粪肠球菌分别为72.73%和100.00%,屎肠球菌分别为43.33%和18.33%。结论:肠球菌主要存在于尿液标本中,其中属粪肠球菌与屎肠球菌为最常见,而两者对于各类抗菌药物皆具有不同程度的耐药性,因此临床应根据致病菌株的耐药特点,合理选用抗菌药物。
Objective： To analyze the characteristics of Enterococcus nosocomial infection and its resistance to new antimicrobial agents. Methods： 160 strains of Enterococcus bacteria from the clinical samples from February 2016 to June 2017 were extracted. The bacterial isolation culture, identification and drug susceptibility test results of these strains were statistically analyzed. And the characteristics of Enterococcus nosocomial infection and resistance to antimi- crobial agents were also analyzed. Results： Among the 160 strains of Enterococcus, the detection rate of urine speci- mens was the highest （58.13%）, of which were faecal Enterococcus （55.00%） and Enterococcus faecalis （37.50%）. The resistance rate of enterococcus faecalis to penicillin, erythromycin, rifampicin, ampicillin, ciprofloxacin and levofloxa- cin were all greater than 75.00%. In addition to erythromycin, tetracycline and rifampicin, the drug resistance rate of En- terococcus faecalis was lower than 25.00% （P〈0.05）. The drug resistance rate of enterococcus faecalis and enterococci to vancomycin was 0. Except erythromycin, rifampin are less than 25% （P〈0.05）; Enterococcusfaecalis and Enterococ- cus Jaecium to vancomycin resistance rate was 0, resistant to linezolid was 1.14% in the former and the latter is 0; two strains resistance to high concentrations of gentamicin and streptomycin in high concentration rate is more than 40% （P〉 0.05）; in observation of tetracycline, quinupristin and dalfotristin, the rate of drug resistance of Enterococcus faecalis was 72.73% and 100%; Enterococci was 43.33% and 18.33% respectively. Conclusion： Enterococcus is mainly found in urine specimens, of which the fecal enterococcus and enterococcus is the commonest, and both have different degrees of resistance to various antimicrobial agents. Therefore, according to the resistance characteristics of the pathogenic strain, antibiotics should berationally selected.
作者
魏峰
FENG Wei(Department of Laboratory, The No.2 People＇s Hospital of Nanyang, Nanyang Henan 473012, China)
出处
《抗感染药学》
2018年第2期209-212,共4页
Anti-infection Pharmacy
关键词
肠球菌
医院感染
抗菌药物
耐药性
Enterococcus
nosocomial infection
antimicrobial agents
resistance
