摘要
目的探讨炎琥宁联合干扰素治疗小儿手足口病(HFMD)的临床疗效。方法 90例HFMD患儿为研究对象,按照随机数字表法将患儿分为炎琥宁组、干扰素组及联合组,每组30例。炎琥宁组采用注射用炎琥宁治疗,干扰素组采用重组人干扰素α-2b注射液治疗,联合组采用干扰素联合炎琥宁治疗。观察比较三组患儿用药后临床表现(用药后退热时间、手足口疱疹消退时间、住院时间)及临床疗效。结果联合组患儿用药后退热时间、手足口疱疹消退时间、住院时间均短于炎琥宁组、干扰素组,差异有统计学意义(P<0.05);炎琥宁组与干扰素组上述指标比较差异无统计学意义(P>0.05)。联合组治疗总有效率93.33%显著高于炎琥宁组76.67%和干扰素组73.33%,差异有统计学意义(P<0.05);炎琥宁组与干扰素组总有效率比较差异无统计学意义(P>0.05)。结论炎琥宁联合干扰素治疗小儿HFMD起效快,疗效显著,是一种较理想的用药方案。
Objective To discuss the clinical efficacy of Yanhuning combined with interferon in the treatment of pediatric hand-foot-mouth disease（HFMD）. Methods A total of 90 HFMD children as study subjects were divided by random number table method into Yanhuning group, interferon group and combined group, with 30 cases in each group. Yanhuning group was treated with Yanhuning, interferon group was treated with recombinant human interferon α-2 b injection, and combined group was treated with interferon and Yanhuning. Observation and comparison were made on clinical manifestations（antipyretic time, hand-foot-mouth herpes subsided time and hospitalization time after medication） and clinical efficacy after medication between the three groups. Results Combined group had shorter antipyretic time, hand-foot-mouth herpes subsided time and hospitalization time after medication than Yanhuning group and interferon group, and their difference was statistically significant（P〈0.05）. Yanhuning group had no statistically significant difference in above indicators comparing with interferon group（P〉0.05）. Combined group had significantly higher total treatment effective rate as 93.33% than 76.67% in Yanhuning group and 73.33% in interferon group, and their difference was statistically significant（P〈0.05）. Yanhuning group had no statistically significant difference in total effective rate comparing with interferon group（P〉0.05）. Conclusion Combination of Yanhuning and interferon shows remarkable efficacy in treating pediatric HFMD with rapid onset, and it is ideal medication regimen.
作者
陈江龙
丁永星
池定锐
CHEN Jiang-long, DING Yong-xing, CHI Ding-rui.(Yunfu People＇ s Hospital, Yunfu 527300, Chin)
出处
《中国实用医药》
2018年第9期105-107,共3页
China Practical Medicine
关键词
炎琥宁
干扰素
小儿手足口病
临床疗效
Yanhuning
Interferon
Pediatric hand-foot-mouth disease
Clinical efficacy
