摘要
目的:观察阿糖腺苷联合干扰素α2b雾化吸入治疗小儿疱疹性咽峡炎的临床疗效。方法选取2011年12月至2013年12月诊治的小儿疱疹性咽峡炎患儿58例,按随机数字表法分为观察组和对照组各29例。所有患儿均予儿科护理常规及一般支持治疗,对照组以利巴韦林进行治疗,观察组采用阿糖腺苷联合干扰素α2b雾化吸入进行治疗。观察记录治疗后的退热时间,疱疹消失时间、住院天数及不良反应情况,比较两组的疗效。结果观察组退热时间、疱疹消失时间及住院天数均低于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率(96.6%)显著高于对照组(75.9%),差异有统计学意义(χ^(2)=5.22,P<0.05)。两组均无明显不良反应。结论阿糖腺苷联合干扰素α2b雾化吸入治疗小儿疱疹性咽峡炎疗效好,安全性较高,未见不良反应,值得临床推广。
Objective To observed the clinical effect of vidarabine and interferonα-2b aerosol inhalation in the treatment of children with infantile herpangina.Methods 58 children with infantile herpangina were divided ran-domly into the observation group and control group,29 cases in each group.All children were given theroutine nursing and general supportive therapy.The patients in the control group were treated by ribavirin and those in the observation group treated by vidarabine and interferon aerosol inhalation.The fever clearance time,the disappearance time of her-pes,the days of hospitalization and cases of adverse reaction was observed and recorded.Results The cooling time,bleb disappear time and hospital stay of the observation group were lower than those of the control group,the difference were statistically significant(P<0.05).Comparation of the clinical effects of the two groups showed that the test group were significantly better than those in the control group(P<0.05).The total effective rate in the observation group was 96.6%,which was higher than 75.9%in the control group(χ^(2)=5.22,P<0.05).No obvious adverse e-vents took place in both groups.Conclusion Vidarabine and interferon aerosol inhalation in treating infantile herpan-gina takes a good effect,no obviously adverse reaction and is worth being widely applied in clinic.
作者
李会
邵媛媛
张艳
胡秀娥
Li Hui;Shao Yuanyuan;Zhang Yan;Hu Xiue(Department of Pediatrics,the Hospital of Shouxian County,Anhui 232200,China)
出处
《中国基层医药》
CAS
2014年第S01期12-14,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
疱疹性咽峡炎
阿糖腺苷
干扰素Α
投药
吸入
Herpangina
Vidarabine
Interferon-alpha
Administration,Inhalation
