摘要
目的探讨利多卡因在神经外科手术中对顺阿曲库铵神经肌肉传导的影响。方法选择ASA Ⅰ-Ⅱ级，择期全身麻醉下行神经外科手术的患者60例，随机分为利多卡因组（L组）和对照组（S组）；L组于诱导时静脉推注利多卡因1.5 mg/kg，然后以3 mg/（kg·h）的速度持续输注至术毕；S组给予相同容量的氯化钠注射液。记录并比较两组肌松药起效时间[顺阿曲库铵静脉注射后4个成串刺激（TOF）＝0的时间]、肌松药恢复时间（TOF＝3至TOF恢复为25%的时间）及肌松药维持时间（TOF＝3至TOF恢复为50%的时间）；记录并比较两组术中顺阿曲库铵的平均用量及血流动力学变化。结果L组与S组肌松药起效时间比较差异未见统计学意义（P〉0.05），两组肌松药恢复时间和肌松药维持时间比较差异均有统计学意义（P均〈0.05）；S组术中顺阿曲库铵的平均用量少于L组（P〈0.05）。结论利多卡因不影响顺阿曲库铵神经肌肉传导阻滞的起效时间，但能延长肌松效应维持时间。
Objective To investigate the effects of lidocaine on cisatracurium neuromuscular conduction in neurosurgery.Methods Sixty patients with ASA Ⅰ-Ⅱ grade who were going to undergo neurologist surgery under general anesthesia were randomly allocated to group L （lidocaine group） and group S （control group）. Group L was injected with 1.5 mg/kg lidocaine intravenously in induction phase, and then was injected with it continuously at speed of 3 mg/（kg·h） till the suturing; group S received sodium chloride injection of same dosage. Muscle relaxant onset time （when TOF=0 after cisatracurium infusion）, muscle relaxant recovery time （from TOF=3 to 25% of TOF recovered）, muscle relaxant maintenance time （from TOF=3 to 50% of TOF recovered） of the two groups were recorded and compared; intraoperative mean dosage of cisatracurium and changes of hemedynamics of the two groups were recorded and compared.Results There was no significant difference in muscle relaxant onset time between group L and group S （P〉0.05）, and were significant differences in muscle relaxant recovery time and muscle relaxant maintenance time between the two groups （both P〈0.05）. Compared with group L, the average consumption of cisatracurium was lower in group S （P〈0.05）.Conclusions Lidocaine does not effect cisatracurium neuromuscular block onset time, but can prolong the duration of the muscle relaxant effect.
作者
李征
连洋洋
贾佳
陈超
Li Zheng , Lian Yangyang, Jia Jia, Chen Chao(Department of Anesthesiology, Henan Provincial People＇ s Hospital, Zhengzhou 450003, Chin)
出处
《中国实用医刊》
2018年第5期7-9,共3页
Chinese Journal of Practical Medicine
