摘要
目的评价5种中药注射剂联合柳氮磺吡啶治疗溃疡性结肠炎的效果。方法通过检索中外文献数据库和相关学术组织网站获取中药注射剂联合柳氮磺吡啶治疗溃疡性结肠炎的随机对照临床试验,根据纳入与排除标准对文献进行筛选并提取数据,采用Cochrane偏倚风险评估工具评价文献质量,采用Open BUGS软件进行网状meta分析。结果共纳入5个随机对照临床试验,5种中药注射剂,511名参与者。网状Meta分析结果显示5种中药注射剂联合柳氮磺吡啶治疗溃疡性结肠炎效果的差异无统计学意义(P>0.05)。结论联合中药注射剂不能提高柳氮磺吡啶治疗溃疡性结肠炎的疗效。
Objective To assess the clinical effects of five traditional Chinese medicine injection（TCMI）combined with sulfasalazine in the treatment of ulcerative colitis.Methods The randomized controlled trials（RCTs）of traditional Chinese medicine injections were searched from domestic and foreign databases.The RCTs were screened according to the predefined inclusion and exclusion criteria,the related items were used to assess the quality of RCTs,and Open BUGS was used for network meta-analysis.Results A total of 5 RCTs were included,involving 5 TCMIs and 511 participants.Network metaanalysis showed that there was no statistical difference among the 5 TCMIs in terms of their effect in the treatment of ulcerative colitis after combined with sulfasalazine.Conclusion A combination with the Traditional Chinese medicine injection cannot improve the efficacy of sulfasalazine in the treatment of ulcerative colitis.
作者
冯锦山
李金宇
杨月娥
陈秀炎
杨正
FENG Jin-shan1,2, LI Jin-yu3, YANG Yue-e3, CHEN Xiu-yan3, YANG Zheng4(1. Scientific Research Center; 2. College of Pharmacy; 3. First College of Clinical Medicine; 4. The Affiliated Hospital of Guangdong Medical University, Zhanjiang 524023, Chin)
出处
《广东医科大学学报》
2017年第5期496-499,共4页
Journal of Guangdong Medical University
基金
广东省医学科技研究基金项目(No.A2015481)
广东省中医药局基金项目(No.20171152)
广东医科大学博士科研启动基金项目(No.B2014004)
关键词
中药注射剂
柳氮磺吡啶
溃疡性结肠炎
网状Meta分析
traditional Chinese medicine injection
salazosulfapyridine
ulcerative colitis
network meta-analysis
