摘要
目的:研究左卡尼汀口服溶液对肾病综合征患儿的降脂效果。方法:将60例肾病综合征患儿以随机数表法分为试验组和对照组各30例。对照组给予常规激素治疗,试验组在此基础上加用左卡尼汀口服溶液100 mg/(kg·d)随餐口服(最大日剂量不超过3 g)治疗,比较两组患儿治疗前、治疗后1个月、2个月的血脂水平(TC、TG、HDL-C、LDL-C)、血浆白蛋白(ALB)、尿蛋白(24 h UP)情况。结果:试验组和对照组的总有效率分别为93.34%和70.00%。在治疗1个月后和2个月后,实验组患儿血中的TC、TG、LDL-C均低于对照组,差异均有统计学意义(P<0.05);试验组患儿血浆ALB水平高于对照组,差异有统计学意义(P<0.05)。结论:左卡尼汀口服溶液对肾病综合征患儿有良好的降脂效果,值得临床推广应用。
Objective： To study the lipid-lowering efficacy of levocaruitine oral solution for children with nephrotic syndrome （NS）. Methods： Sixty cases with NS were selected and randomly divided into two groups： 30 cases in control group were treated with routine hormonotherapy, 30 cases in experimental group treated with levocarnitine oral solution and the same therapy as control group. The serum lipid, plasma albumin, 24-hour urinary protein in two groups before and after treatment were compared. Results： The total effective rates in the experimental group and the control group were 93.34% and 70.00% , and after treatment in one and two months, the levels of total cholesterol （TC）, triglycerides （TG） , low-density lipoprotein cholesterol （LDL-C） in the experimental group were significantly lower than those in the control group （P〈0. 05 ）, plasma albumin （ALB） of the experimental group was significantly higher than the control group （P〈O. 05）. Conclusion： Levocarnitine oral solution had good effect on lipid-lowering in children with NS and it is worthy of widely using clinically.
作者
杨琴
周太光
Yang Qin, Zhou Taiguang(The Affiliated Hospital of Southwest Medical University, Sichuan Luzhou 646000, Chin)
出处
《儿科药学杂志》
CAS
2018年第4期20-23,共4页
Journal of Pediatric Pharmacy
关键词
左卡尼汀口服液
肾病综合征
血脂
levocarnitine oral solution
nephrotic syndrome
serum lipid
