摘要
代谢综合征是一组以肥胖、血脂异常、高血压、高尿酸血症、高血糖以及胰岛素抵抗等为主要特征的临床综合征,是心血管疾病和糖尿病的重要危险因素。研究表明,左旋肉碱,即L-肉碱,对代谢综合征具有潜在改善作用。本文对人体L-肉碱的来源及L-肉碱改善代谢综合征主要组分,如肥胖、血脂异常等的作用及机制进行综述,并讨论了L-肉碱作为氧化三甲胺前体物质的潜在健康风险问题,为代谢综合征的防治及L-肉碱的合理摄食补充及应用提供理论依据及参考。
Metabolic syndrome is a group of clinical syndromes,including obesity,dyslipidemia,hypertension,hyperuricemia,hyperglycemia and insulin resistance.These syndromes are critical risk factors for cardiovascular disease and diabetes.Recent studies indicate that L-carnitine exhibits potential improvement effects on metabolic syndrome.In the current study,the sources of L-carnitine for human and the effects and mechanisms of L-carnitine on the major components of metabolic syndrome,such as obesity and dyslipidemia,etc were summarized.The potential health risk of L-carnitine by serving as a dietary precursor for trimethylamine N-oxide was also discussed.This study provides theoretical basis and references for the treatment of metabolic syndrome and the rational dietary supplement and utilization of L-carnitine.
作者
孙诚园
张毓玲
陈芊汝
李江萍
李涛
魏玉西
高翔
SUN Chengyuan;ZHANG Yuling;CHEN Qianru;LI Jiangping;LI Tao;WEI Yuxi;GAO Xiang(College of Life Sciences,Qingdao University,Qingdao 266071,China;College of Food Science and Engineering,Qingdao Agricultural University,Qingdao 266109,China;Anqiu Huatao Food Co.,Ltd.,Weifang 262100,China)
出处
《食品工业科技》
CAS
北大核心
2023年第1期475-484,共10页
Science and Technology of Food Industry
基金
山东省自然科学基金项目(ZR2019PC014)
中国博士后基金面上项目(2019M652327)。
关键词
左旋肉碱
代谢综合征
改善作用
机制
氧化三甲胺
L-carnitine
metabolic syndrome
improvement effects
mechanisms
trimethylamine N-oxide
