摘要
肝纤维化是肝应对损伤的一种修复反应。肝星状细胞活化是肝纤维化的中心环节,这一过程涉及Hippo,Notch,Wnt/β-catenin,TGF-β/Smad等多条信号通路。YAP/TAZ是Hippo肿瘤抑制途径的一个重要细胞核影响因子,其活性是整个器官生长、细胞增殖以及细胞在组织更新与再生过程中特异性扩增的关键。YAP/TAZ蛋白作为枢纽可能通过调控Hippo,Notch,Wnt/β-catenin,TGF-β/Smad通路影响肝纤维化的发生与发展。
Hepatic fibrosis is a repair response to liver injury, and hepatic stellate cell activation is the center of hepatic fibrosis, which involves Hippo, Notch, Wntβ-catenin, and TGF-β/Smad signaling pathways. YAP/TAZ is an important nucleus factor for Hippo tumor suppressor pathway and its activity is the key to the growth of whole organs, cell proliferation, and specific amplification of progenitor cells in the process of tissue renewal and regeneration. As the hub of signalin such as Hippo, Notch, Wnt β-catenin, TGF-β/Smad signaling, YAP/TAZ regulates the g pathways, genesis and development of liver fibrosis.
作者
潘火珍
廖明
宋鹏书
PAN Huozhen, LIAO Ming, SONG Pengshu(Life Science Institutej Guangxi Medical University, Nanning 530021, Chin)
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2018年第3期313-319,共7页
Journal of Central South University ：Medical Science
基金
国家自然科学基金(81460128)
区域性高发肿瘤早期防治研究教育部重点实验室项目(GKE2017-ZZ09)~~
