摘要
高脂血症相关胰腺炎的发病率逐年增加,重症率也不断上升。由于临床对其发病机制认识不足,易导致疾病延误治疗。内质网应激不仅参与高脂血症相关胰腺炎的发生,同时也是介导疾病进一步加重的主要机制之一。因此,增加对内质网应激相关分子的研究,可能为高脂血症相关胰腺炎的早期预警和临床治疗提供新的靶点。
The incidence of hyperlipidemic pancreatitis is increasing with years. The pathogenesis of hyperlipidemic pancreatitis has not been recognized, which is responsible for the misdiagnose and delayed treatment of the disease. Endoplasmic retieulum stress is involved in the pathogenesis and aggravation of hyperlipidemie pancreatitis. Endoplasmie reticulum stress related molecules may provide new targets for early diagnosis and clinical treatment of hyperlipidemic panereatitis.
作者
李菁
商中华
陈恩明
The Second Clinical Medical College, Shanxi Medical University, Taiyuan 030001, China(Li J, Chen EM ） ; Department of General Surgery, Second Hospital of Shanxi Medical University, Taiyuan 030001, China （Shang ZH)
出处
《中国医药》
2018年第3期474-477,共4页
China Medicine
关键词
胰腺炎
高脂血症
内质网应激
细胞凋亡
Pancreatitis
Hyperlipidemia
Endoplasmic reticulum stress
Apoptosis
