摘要
血管内皮生长因子（vascular endothelial growth factor, VEGF）在脑缺血后的血管生成和血管再生中起着重要的作用。一方面，VEGF通过促进血管生成和神经发生发挥神经保护作用；另一方面，VEGF诱导的内皮细胞通透性可造成BBB功能障碍。运动预处理能上调VEGF表达，通过增强脑微血管完整性减轻缺血性脑损伤。VEGF可作为缺血性卒中的治疗靶点。
Vascular endothelial growth factor （VEGF） plays an important role in angiogenesis and vascular regeneration after cerebral ischemia. On one hand, VEGF plays a neuroprotective effect by promoting angioganesis and neuroganesis; on the other hand, VEGF induced endothelial permeability can cause blood-brain barrier （BBB） dysfunction. Exercise preconditioning can up-regulate the expression of VEGF and reduce the ischemic brain damage by enhancing the cerebral microvascular integrity. VEGF can be used as a therapeutic target for ischemic stroke.
作者
马彤
张艳
周珊珊
Ma Tong;Zhang Yan;Zhou Shanshan(Department of Neurology, the First Affiliated Hospital of Hebin Medical University, Harbin 150001, China)
出处
《国际脑血管病杂志》
2018年第1期47-50,共4页
International Journal of Cerebrovascular Diseases
关键词
卒中
脑缺血
血管内皮生长因子A
新生血管化
生理性
血脑屏障
神经保护药
Stroke
Brain Ischemia
Vascular Endothelial Growth Factor A
Neovascularization, Physiologic
Blood-Brain Barrier
Neuroprotective Agents
