摘要
拉曼光谱分析技术可以在分子水平上研究物质分子结构和生化组成信息,具有快速、准确、无创(或低创)等优点,已成为临床早期癌症检测和组织病理生理分析的重要工具。近年来,激光技术、光纤探测器件和光电检测技术的发展,不仅极大促进了新型拉曼光谱分析仪器与技术的研发,更进一步扩展了其临床应用的广度和深度,彰显出其独特的科学内涵与应用价值。对临床拉曼光谱分析技术的理论基础进行了阐述,归纳总结了临床快速拉曼光谱分析集成系统设计思路。在此基础上,以作者相关研究工作为例,探讨了拉曼光谱分析技术在临床癌症早期检测与病理分析中的应用特点,为推动相关基础研究及技术创新提供有益参考。
Raman spectroscopy（RS）is a unique analytical technique that probes molecular vibrations,and provides specific information about the structure and conformation of biomolecular constituents in biological tissues.Its capabilities for fast,accurate,and noninvasive/minimally invasive analysis have facilitated clinical applications in early cancer detection and pathophysiological investigations.Recent technology advancement in lasers,optical fiber probes and photoelectric devices has resulted in new rapid Raman spectroscopy systems with significantly better performance for real-time clinical measurements.Thereby,the scope and depth of its clinical usages have been expanded and deepened with the manifestation of its scientific connotation and diagnostic value.This short review provided an introduction to the theory and technology behind the development of integrated real-time Raman systemfor in vivo cancer detection.The perspective of its clinical utility,exemplified with skin and lung cancer detection,was presented with the intention of providing a useful reference for relevant basic research and technical innovation.
作者
王爽
Haishan Zeng
Shuang Wang1, Haishan Zeng2,3(1 Institute of Photonics and Photon-Technology, Northwest University, Xi＇an, Shaanxi 710069, China ; Imaging Unit-Integrative Oncology Department, BC Cancer Agency Research Centre, Vancouver, British Columbia VSZ 1L3, Canada; 3 Photomedicine Institute, Department of Dermatology and Skin Science, University of British Columbia Vancouver, British Columbia V5Z 4E8, Canad)
出处
《中国激光》
EI
CAS
CSCD
北大核心
2018年第2期35-49,共15页
Chinese Journal of Lasers
基金
National Cancer Institute of Canada(011031,015053,020352)
Canadian Institutes of Health Research(PPP-79109,PP2-111527,MOP130548,201603PJT-364146-PJT-CAAA-60404)
国家自然科学基金(11404258)
陕西省教育厅科研计划(15JS102)
陕西省重大基础研究项目(2016ZDJC-15)
关键词
医用光学
拉曼光谱
早期癌症诊断
临床检测仪器
皮肤癌
肺癌
medical optics
Raman spectroscopy
early cancer detection
clinical instrument
skin cancer
lungcancer
