摘要
目的探讨肝硬化合并感染患者营养状况及免疫功能的变化。方法选取肝硬化合并感染患者95例为研究组,另选取单纯肝硬化患者和健康体检者各95例作为对照。采用免疫投射比浊法检测血清营养因子变化;化学发光免疫分析法检测血清免疫球蛋白及补体变化;流式细胞仪检测外周血淋巴细胞亚群变化。结果研究组患者血清中TP、ALB、Pre ALB、TG、TC和LDL浓度均低于肝硬化对照组和健康对照组,GLB高于肝硬化对照组和健康对照组;与肝硬化对照组和健康对照组相比,研究组患者外周血CD3+、CD4+、CD8+、CD16++CD56+水平明显降低,Ig G、Ig A明显上升,补体C3和C4含量显著下降,差异均有统计学意义(P<0.05)。结论肝硬化合并感染患者营养状况和免疫功能发生进一步恶化,改善肝硬化患者营养状况,提高免疫力,加强卫生护理,对预防肝硬化合并细菌感染具有积极作用。
Objective To explore the changes of nutritional status and immol/Lune function of liver cirrhosis patients with bacterial infection. Methods A total of 95 liver cirrhosis patients with bacterial infection were collected. 95 patients with liver cirrhosis alone and 95 healthy people were collected as control group,respectively. The changes of serum nutritional factors were detected by immunoprecipitation turbidimetry,the changes of serum immunoglobulin and complement were detected by chemiluminescence immunoassay, and the changes of peripheral blood lymphocyte subsets were detected by flow cytometry.Results Serum levels of TP,ALB,Pre ALB,TG,TC and LDL in study group were lower than those in cirrhosis control group and healthy control group,GLB was higher than that in cirrhosis control group and healthy control group,and cirrhosis control group and healthy control group compared with the control group; the levels of CD3＋,CD4＋,CD8＋,CD16＋＋ CD56＋,Ig G and Ig A in the peripheral blood of the study group significantly increased,while the contents of C3 and C4 significantly decreased,with all the differences statistically significant（ P〈0. 05）. Conclusion The nutritional status and immol/Lune function of liver cirrhosis patients with bacterial infection were further aggravated. Therefore,improving the nutritional status and immol/Lune function and strengthening health care for liver cirrhosis patients have a positive effect for preventing against bacterial infection.
作者
黄振强
郑海雅
曲春生
王朋
戴数
HUANG Zhen -qiang, ZHENG Hai -ya, QU Chun -sheng, WANG Peng, DAI Shu(Clinical Laboratory, Lishui People＇s Hospital, Lishui, Zhejiang 323000, Chin)
出处
《中国卫生检验杂志》
CAS
2018年第4期473-475,共3页
Chinese Journal of Health Laboratory Technology
基金
2011年丽水市科技局自筹经费科技项目(2011-17)
关键词
肝硬化
感染
营养状况
免疫功能
淋巴细胞亚群
Liver cirrhosis
Bacterial infection
Nutritional status
Immol/Lune function
Lymphocyte subsets
