摘要
目的探讨乙醛脱氢酶1(ALDH1)蛋白在膀胱癌组织中的表达情况及其与膀胱癌发生、发展的关系。方法收集100例经手术后切除的膀胱癌组织及相应的40例膀胱癌癌旁正常膀胱组织,采用免疫组化染色方法检测膀胱癌组织和癌旁正常膀胱组织中ALDH1蛋白的表达,分析其与膀胱癌患者临床病理特征的关系,并探讨其与膀胱癌发生、发展的关系。结果膀胱癌组织中ALDH1蛋白的阳性表达率(42.00%)明显高于癌旁正常膀胱组织(5.00%),差异有统计学意义(P﹤0.01);有脉管浸润、有神经浸润、有淋巴结转移、T2~4期膀胱癌组织中ALDH1蛋白的阳性表达率均高于无脉管浸润、无神经浸润、无淋巴结转移、T_(a^1)期的膀胱癌组织,差异均有统计学意义(P﹤0.05)。结论 ALDH1蛋白在膀胱癌组织中的阳性表达水平高,并且与肿瘤的发生、发展有关。
Objective To investigate the expression of ALDH1 protein in bladder cancer and its relationship with tumorigenesis and development of bladder cancer. Method 100 cases of bladder cancer tissues and 40 cases of adjacent normal tissues of bladder cancer were collected, of which the expression of ALDH1 protein was detected by immunohistochemical staining to investigate the relationship with the clinicopathological characteristics, occurrence and development of bladder cancer. Result The positive expression rate of ALDH1 protein in bladder cancer tissues（42.00%） was significantly higher than that in adjacent normal tissues（5.00%）, the difference was statistically significant（P〈0.01）; presence of vascular invasion, neural invasion, lymph node metastasis, with bladder cancer tissues of stage T2~4 were associated with significantly higher positive expression rate of ALDH1 protein compared with those without vascular invasion,neural invasion, lymph node metastasis, or without bladder cancer tissues of stage Ta^1, demonstrating significant differences（P〈0.05）. Conclusion The positive expression level of ALDH1 protein in bladder cancer tissues increased significantly, and was correlated with the occurrence and development of tumor.
出处
《癌症进展》
2018年第2期183-185,共3页
Oncology Progress
关键词
乙醛脱氢酶1
膀胱癌
表达
临床病理特征
aldehyde dehydrogenase 1
bladder cancer
expression
clinicopathological features
