摘要
目的测定近交系CMU/1和CMU/2长爪沙鼠和近交系F344大鼠及BALB/c小鼠4项凝血指标,比较不同动物间差异,明确脑缺血模型近交系长爪沙鼠的凝血特性。方法采用MC-4000四通道血凝仪检测4组动物凝血酶原时间(PT)、部分凝血活酶时间(APTT)、纤维蛋白原(FIB)和凝血酶时间(TT)。应用SPSS23.0软件对数据进行统计分析。结果 CMU/1的APTT、FIB和CMU/2的FIB标准差较大;CMU/1和CMU/2的PT、FIB与F344大鼠差异显著,APTT与BALB/c小鼠和F344大鼠差异显著。结论脑缺血模型长爪沙鼠近交系动物凝血4项指标与近交系BALB/c小鼠接近,与近交系F344大鼠差异显著。
Objective To detect and compare the differences of coagulation factors between inbred gerbil CMU/1 and CMU/2, inbred rat F344, and inbred mouse BALB/c; then to analyze the characteristics of inbred ischemia-prone gerbil. Methods The four channel blood coagulation analyzer was used to determine three kinds of inbred animals＇ plasma prothrombin time （PT）, activated partial thromboplastin time （APTT）, fibrinogen （FIB）, and thrombin time （TT）. The SPSS23.0 software was applied for statistical analysis of data. Results The APTT FIB of CMU/1 and the FIB of CMU/2 of ischemia-prone gerbil displayed high standard deviation. The PT and FIB of CMU/1 and CMU/2 showed significantly different compared with that of F344 rat. The APTT of both ischemia-prone inbred gerbil lines demonstrated significant difference compared with BALB/c mouse and F344 rat. Conclusion The 4 coagulation factors of ischemia-prone inbred gerbil lines are consistent With those of inbred BALB/c mouse; which are significantly different from those of inbred F344 rat.
出处
《实验动物与比较医学》
CAS
2018年第1期57-59,共3页
Laboratory Animal and Comparative Medicine
基金
国家科技支撑计划课题(2015BAI09B01-04)
