摘要
目的测定并比较SD大鼠、Wistar大鼠、ICR小鼠和长爪沙鼠的部分凝血因子的凝血时间。方法采用四通道血凝仪检测4种动物的血浆凝血酶原时间(PT)、部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、凝血酶时间(TT)。结果SD大鼠、Wistar大鼠、ICR小鼠和长爪沙鼠的TT分别为31.72 s、47.35 s、106.34 s和35.96 s;APTT分别为17.66 s、20.49 s、20.74 s和16.27 s;FIB分别为20.45 s、18.20 s、22.81 s和21.35 s;PT分别为21.00 s、21.76 s、16.74 s和25.16 s;ICR小鼠的TT值与其他3种动物间、SD大鼠与Wistar大鼠间有显著差异(P<0.05);ICR小鼠和长爪沙鼠的PT有显著差异(P<0.05);ICR小鼠与Wistar大鼠和SD大鼠间、Wistar大鼠与SD大鼠和长爪沙鼠间的APTT差异显著(P<0.05);ICR小鼠与SD大鼠和长爪沙鼠间、SD大鼠与Wistar大鼠间、Wistar大鼠与长爪沙鼠间的FIB差异显著(P<0.05)。结论SD大鼠、Wistar大鼠、ICR小鼠和长爪沙鼠的部分凝血因子的凝血时间有较大差异。
Objective To test coagulation time of four kinds of coagulation factors in ICR mice, SD rats, Wistar rats, and Mongolian gerbils and compare difference in coagulation time of four kinds of coagulation factors among the animals. Methods Prothrombin time （PT）, activated partial thromboplastin time （APPT）, fibrinogen time （FIB）, and thrombin time （TT） were tested by HemoClot MC-2000plus in ICR mice, SD rats, Wistar rats, and Mongolian gerbils. Results TT in SD rats, Wistar rats, ICR mice, and Mongolian gerbils was respectively 31.72 s, 47.35 s, 106.34 s, and 35.96 s; APPT was respectively 17.66 s, 20.49 s, 20.74 s and 16.27 s; FIB was respectively 20.45 s, 18.20 s, 22.81 s, and 21.35 s; PT was respectively 21.00 s, 21.76 s, 16.74 s, and 25.16 s. The differences in TT between ICR mice and other 3 kind of animals, and between SD rats and Wistar rats were significant （ P 〈 0.05） ; the difference in PT between ICR mice and Mongolian gerbils was significant （ P 〈 0.05） ; the differences in APTT between ICR mice and Wistar rats, between ICR mice and SD rats, between Wistar rats and SD rats, and between Mongolian gerbils and Wistar rats were significant （P 〈 0.05）; and the differences in FIB between ICR mice and SD rats, between ICR mice and Mongolian gerbils, between SD rats and Wistar rats, and between Wistar rats and Mongolian gerbils were significant （ P 〈 0.05）. Conclusion There were significant differences in PT, APPT, FIB, and TT among SD rats, Wistar rats, ICR mice, and Mongolian gerbils.
出处
《实验动物科学》
2007年第5期1-3,42,共4页
Laboratory Animal Science
