摘要
目的系统评价长链非编码RNA(Lnc RNA)表达水平与胃癌患者临床特征及预后价值的关系。方法计算机检索Pub Med、EMbase、The Cochrane Library、Web of Science、CNKI、VIP、Wan Fang Data和CBM数据库,搜集有关Lnc RNA高表达与胃癌预后相关性的研究,检索时限均为建库至2017年4月。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Stata 12.0软件进行Meta分析。结果共纳入21个病例-对照研究。Meta分析结果显示:Lnc RNA高表达胃癌患者TNM分期较晚[OR=0.29,95%CI(0.24,0.35),P<0.001]、浸润更深[OR=0.24,95%CI(0.12,0.49),P<0.001]、总生存期(OS)[HR=2.52,95%CI(2.07,3.06),P<0.001]及无病生存期(DFS)[HR=2.31,95%CI(1.75,3.05),P<0.001]更短。结论胃癌患者Lnc RNA高表达是胃癌预后不良的危险因素。受纳入研究数量和质量的限制,上述结论尚待开展更多高质量研究予以验证。
Objectives To systematically review the association between the expression level of LncRNA and clinicopathological features and prognostic value of gastric cancer. Methods We searched PubMed, EMbase, The Cochrane Library, Web of Science, CNKI, VIP, WanFang Data and CBM databases to collect studies on the association between LncRNA overexpression and prognosis for gastric cancer from inception to April 2017. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies, then, meta-analysis was performed by using Stata 12.0 software. Results A total of 21 case-control studies were included. The results of meta- analysis showed that： LncRNA overexpression patients had poor TNM stage （OR=0.29, 95%CI 0.24 to 0.35, P〈0.001）, deeper tumor invasion （OR=0.24, 95%CI 0.12 to 0.49, P〈0.001）, shorter overall survival （OS） （HR=2.52, 95%CI 2.07 to 3.06, P〈0.001） and disease-free survival （DFS） （HR=2.31, 95%CI 1.75 to 3.05, P〈0.001）. Conclusions LncRNA overexpression is a poor prognosis risk factor for gastric cancer patients. Due to limited quantity and quality of the included studies, more high quality studies are needed to verify above conclusions.
出处
《中国循证医学杂志》
CSCD
北大核心
2018年第3期286-293,共8页
Chinese Journal of Evidence-based Medicine
基金
国家自然科学基金项目(编号:31670847)
甘肃省卫生行业科研计划项目(编号:GSWSK2016-03)
