摘要
目的:研究雷贝拉唑治疗老年慢性萎缩性胃炎的疗效及对血清胃泌素(Gastrin,GAS)和内皮素(Endothelin,ET)水平的影响。方法:选取2014年7月至2015年7月我院接诊的100例老年慢性萎缩性胃炎患者为研究对象,随机分为对照组和观察组(每组50例)。对照组采用奥美拉唑(20mg/次,2次/d)、左氧氟沙星(0.2g/次,2次/d)、呋喃唑酮(100mg/次,3次/d)进行治疗,观察组采用雷贝拉唑(20mg/次,1次/d)、左氧氟沙星(0.2g/次,2次/d)、呋喃唑酮(100mg/次,3次/d)进行治疗,治疗共持续2周。观察两组患者治疗前后血清胃泌素(Gastrin,GAS)和内皮素水平(Endothelin,ET)、治疗后不良反应情况和治疗疗效。结果:治疗后,观察组GAS水平(176.38±13.29)ng/L高于对照组(142.27±12.32)ng/L,ET水平(62.82±5.72)ng/L低于对照组(78.39±6.59)ng/L,差异具有统计学意义(P<0.05);观察组不良反应总发生率10.00%(5/50)小于对照组38.00%(19/50),差异具有统计学意义(P<0.05);观察组总有效率94.00%(47/50)优于对照组76.00%(38/50),差异具有统计学意义(P<0.05)。结论:雷贝拉唑治疗老年慢性萎缩性胃炎疗效显著,能够显著提高血清胃泌素的水平,降低内皮素的水平,减少并发症的发生。
Objective： To study the effect of Ray Bella in the treatment of senile chronic atrophic gastritis and its influence on the serum levels of Gastrin and Endothelin. Methods： 100 cases of elderly patients with chronic atrophic gastritis admitted in our hospital from July 2014 to July 2015 were selected and randomly divided into observe group and control group（50 cases in each group）. Patients in the control group were given omeprazole（20 mg/time,2 time/day）,levofloxacin（0.2 g/time,2 time/day）,and furazolidone（100 mg/time,3 time/day）. Patients in the observation group were given rabeprazole azole（20 mg/time,1 time/day）,levofloxacin（0.2 g/time,2 time/day）,furazolidone（100 mg/time,3 time/day）. The treatments for patients in both groups were last two weeks. After treatment,the serum levels of gastrin and endothelin,the adverse reactions and the efficacy between treatments were compared. Result After treatment,the GAS and ET levels in patients of the observation group were（176. 38 ± 13. 29） ng/L,which higher than that in patients of the control group（142.27±12.32） ng/L; While,serum ET level（62.82±5.72） ng/L were lower than that in patients of the control group（78.39±6.59） ng/L. The differences of the two items were all statistically significant（P 〈 0.05）.The incidence rates of adverse reactions in observation group was 10.00%（5/50 cases）,which less than that in the control group 38.00%（19/50 cases）. The difference was statistically significant（P 〈0.05）. The total effective rate of the observation group was 94.00%（47/50 cases）,which higher than that in the control group76.00%（38/50）. The difference was statistically significant（P 〈0.05）; Conclusion： Ray Bella has a significant effect in the treatment of chronic atrophic gastritis in elderly patients,which could significantly improve the level of serum gastrin,reduce the level of endothelin,and reduce the incidence of complications.
出处
《河北医学》
CAS
2018年第2期321-325,共5页
Hebei Medicine
基金
辽宁省自然科学基金资助项目
(编号:20052070)
