摘要
目的:评价临床药学服务对幽门螺杆菌(H.pylori)阳性消化性溃疡患者用药依从性及治疗效果的影响。方法:前瞻性纳入2015年7月-2016年6月我院消化内科门诊H.pylori阳性消化性溃疡患者96名,随机分为对照组和干预组,对照组予常规门诊服务,干预组予用药教育及随访。分别于根除H.pylori治疗前后对患者用药依从性、胃肠道症状进行评分,抗酸治疗结束至少4周后^(14)C尿素呼气试验复查H.pylori根除率。结果:临床药学服务干预组患者用药依从性评分显著高于对照组(3.73 vs.2.58,P<0.01),提高程度具有显著性差异(1.71 vs.0.44,P<0.01),干预组患者的完全服药率为81.25%,对照组为60.42%,差异有统计学意义(P<0.05);干预组胃肠道症状改善44人,对照组36人(91.67%vs.75.00%,P<0.05);HP根除率干预组显著高于对照组(91.67%vs.72.92%,P<0.05)。结论:临床药学服务能显著提高门诊消化性溃疡患者根除H.pylori治疗的用药依从性和H.pylori根除率,并改善患者胃肠道症状。
AIM： To assess the influence of clinical pharmaceutical care on medication compliance and treatment effect in Helicobacter pylori（ H.pylori） eradication in outpatients with peptic ulcer.METHODS： Ninety-six outpatients with H. pylori positive peptic ulcer from July 2015 to June 2016 were prospectively collected and were randomly divided into control group and intervention group. Patients in the control group were given the traditional outpatient service. The intervention group patients received pharmaceutical education and follow-up by clinical pharmacist. Medication compliance and gastrointestinal symptom were assessed in both groups before and after H. pylori eradication therapy. H. pylori eradication rates of all patients were tested by ^（14）C urea breath test after the end of stopping all medicines for at least 4 weeks. RESULTS： The score and the improvement of compliance with medication of intervention group patients were significantly higher than those of the control group（ 3. 73 vs.2. 58,1. 71 vs. 0. 44,P 0. 01）. 81. 25% of patients in intervention group and 60. 42% of patients in control group took all prescribed doses. The difference was statistically different（ P 0. 05）.Forty-four patients of the intervention group and thirty-six patients in the control group reported less gastrointestinal symptoms（ 91. 67% vs. 75. 00%,P 0. 05）. The H. pylori eradication rate of the intervention group was significantly higher than that of the control group（ 91. 67% vs. 72. 92%, P 0. 05）. CONCLUSION： Clinical pharmaceutical care has a significant effect on H. pylori eradication rate,medication compliance and the improvement of gastrointestinal symptom.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2018年第2期199-204,共6页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
江苏省药学会-奥赛康医院药学科研项目(201408)
关键词
临床药学服务
根除幽门螺杆菌
消化性溃疡
用药依从性
clinical pharmaceutical care
Heli-cobacter pylori eradication
peptic ulcer
medicationcompliance
