摘要
目的了解江苏省苏州市幽门螺杆菌(H.pylori)对抗生素的耐药情况,为提高幽门螺杆菌感染根除率提供依据。方法收集经胃镜活检快速尿素酶阳性的慢性胃炎及消化性溃疡患者506例,取胃窦黏膜组织,常规方法培养鉴定幽门螺杆菌,并对分离菌株进行药敏纸片法(KB)鉴定。结果结果506例慢性胃炎及消化性溃疡患者中,幽门螺杆菌分离率为76.1%;H.pylori对甲硝唑和克拉霉素的耐药率均较高,分别为75.5%及19.4%(P<0.001,P<0.05);对阿莫西林、呋喃唑酮、左氧氟沙星、头孢呋辛、莫西沙星仍保持较高的敏感性,耐药率依次分别为3.6%,2.2%,7.2%,0.0%,5.8%;H.pylori的快速尿素酶试验(RUT)阳性程度越强,培养阳性率就越高。结论苏州地区H.pylori根除治疗的抗生素应首选阿莫西林,呋喃唑酮、头孢呋辛、左氧氟沙星、莫西沙星等药物,避免使用甲硝唑,慎重选择克拉霉素。
Objective To determine the antibiotic resistance of Helicobacter pylori（H.pylori） strains isolated from the patients with chronic gastritis or peptic ulcer in Suzhou area,and to provide information for control of H.pylori infection.Methods H.pylori was isolated from gastric mucosal biopsy specimens obtained from 506 patients with positive rapid urease test （RUT） result.The susceptibility to antibiotic was determined by Kirby-Baner test.Results The positive rate of isolated H.pylori strains was 76.1% among 506 patients.Overall the resistance rates for metronidazole and clarithromycin were 75.5% and 19.4%,respectively（P0.001,P0.05）.But H.pylori remained highly susceptible to amoxicillin,furazolidone,levofloxacin,cefuroxime,and moxifloxacin with resistant rates of 3.6%,2.2%,7.2%,0.0% and 5.8%,respectively.The positive rate of H.pylori cultivation increased with the increase of the positive rate of RUT.Conclusion The first-line antibiotic treatment for H.pylori infection in Suzhou area should be amoxicillin,furazolidone,levofloxacin,cefuroxime or moxifloxacin,and exckyde metronidazole.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2010年第1期122-123,共2页
Chinese Journal of Public Health
关键词
幽门螺杆菌
分离培养
耐药性
胃肠病患者
Helicobacter pylori
isolated cultivation
drug resistance
patient with gastric or intestinal disease
