摘要
目的探讨2型糖尿病(T2DM)患者外周血中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)与代谢综合征(MS)的相关性。方法将210例T2DM患者根据合并MS组分数目不同,分为不伴有其他MS组分的T2DM组(G0组),合并1个组分的T2DM组(G1组),合并2个组分的T2DM组(G2组),合并3个组分的T2DM组(G3组),检测并比较NLR、PLR及相关代谢指标,分析其与MS的相关性。结果随着MS组分的增多,NLR、PLR、体质指数(BMI)升高,淋巴细胞计数(L)下降,差异具有统计学意义(P<0.05);G1、G2、G3组白细胞计数(WBC)、中性粒细胞计数(N)、纤维蛋白原(FIB)、收缩压(SBP)、舒张压(DBP)、糖化血红蛋白(HbA1c)、甘油三酯(TG)高于G0组,合并高MS组分的G2、G3组病程、WBC、血小板计数(PLT)、HbA1c、高密度脂蛋白(HDL)高于G1组,差异具统计学意义(P<0.05);NLR、PLR的AUC>0.7,差异具有统计学意义(P<0.001);NLR、PLR、BMI、HbA1c、TG升高与HDL降低是代谢综合征严重程度的独立危险因素,差异具有统计学意义(P<0.05)。结论 NLR、PLR可以作为辅助评估T2DM患者合并MS严重程度的独立预测指标。
Objective To investigate the association between the association analysis between neutrophil to lymphocyte ratio（NLR）,platelet to lymphocyte ratio（PLR） and metabolic syndrome（MS） in patients with type 2 diabetes（T2DM）.Methods According to the metabolic abnormalities,210 patients with T2DM were grouped.The diabetes patients without any other metabolic abnormalities were in group 0（G0）.Those with one to three other metabolic abnormalities were divided into group 1（G1）,group 2（G2） and group 3（G3）.Relevant metabolic characteristics were measured and NLR,PLR were calculated which were compared among four groups.The relationship of these indexs and the severity of MS was analyzed.Results Body mass index,NLR,PLR were increased and lymphocyte level was decreased according to the increasing numbers of MS components（P 0.05）; Compared to group 0,the values of White blood cell,neutrophils,plasma fibrinogen,systolic blood pressure,diastolic blood pressure,HbA1c,triglyceride of the other groups were higher（P 0.05）; In high components groups,there were higher values of White blood cell,platelet,Body mass index,HbA1c,triglyceride than the low components ones（P 0.05）.The area under the curve of NLR,PLR were greater than 0.7（P 0.001）.The increased levels of NLR,PLR,Body mass index,HbA1c,triglyceride were risk factors for the severity of MS（P 0.05）.Conclusion NLR and PLR can be used as an adjuvant prognostic markers for the severity of T2DM patients with MS.
出处
《医药论坛杂志》
2017年第11期18-21,共4页
Journal of Medical Forum
基金
河南省科技攻关计划项目(201403159)
