摘要
目的分析巨噬细胞刺激蛋白(MSP)在慢性阻塞性肺疾病(COPD)中的作用及相关机制。方法选取2016年8月至2017年4月我院收治的COPD稳定期患者(缓解组)、COPD急性加重期患者(AECOPD组)及健康体检者(对照组),各45例。所有研究对象均采用酶联免疫吸附法检测血浆MSP水平;同时,检测AECOPD组和缓解期组患者诱导痰中的MSP表达水平。比较三组的1 s用力呼出量(FEV_1)及用力肺活量(FVC)。结果 AECOPD组和缓解期组血浆MSP水平明显高于对照组(P<0.05);AECOPD组患者的血浆和诱导痰MSP水平明显高于缓解期组患者(P<0.05);AECOPD组和缓解期组FEV_1及FVC明显低于对照组,且AECOPD组FEV_1及FVC明显低于缓解期组(P<0.05)。结论 COPD患者血浆和诱导痰MSP水平高,且与患者的肺功能及生活质量密切相关,这可能与MSP调控巨噬细胞参与气道炎症反应相关。因此,作为可能辅助评估患者肺功能及病情的指标,COPD患者血浆和诱导痰MSP可指导医生进行进一步治疗干预。
Objective To investigate the role of macrophage stimulating protein （MSP） in chronic obstructive pulmonarydisease （COPD） and its related mechanism. Methods From August 2016 to April 2017, 45 stable phase COPD patients（stable phase group）, 45 acute exacerbation COPD patients （AECOPD group） and 45 healthy physical examiners （controlgroup） were selected as the study objects. All the study objects received plasma MSP detection by enzyme linkedimmunosorbent assay, and the MSP levels in induced sputum in stable phase group and AECOPD group were detected. Thelevels of forced expiratory volume in1s （FEV1） and forced vital capacity （FVC） were compared among the three groups.Results The plasma MSP levels in the stable phase group and AECOPD group were higher than those in the control group（P约0.05）; and the plasma MSP and induced sputum MSP levels in the AECOPD group were higher than those in the stablephase group（P〈0.05）. The levels of FEV1 and FVC in the stable phase group and AECOPD group were lower than those inthe control group（P〈0.05）; and those in the AECOPD group were lower than the stable phase group（P〈0.05）. ConclusionPlasma and induced sputum MSP levels in COPD patients are associated with the patients＇ lung function and life quality,which may be associated with MSP-regulated macrophages involvement in airway inflammation. Thus, as an indicator thatmay assist in assessing lung function and condition in patients, COPD plasma and induced sputum MSP can further directphysician intervention in its treatment.
出处
《临床医学研究与实践》
2018年第2期88-89,共2页
Clinical Research and Practice
