摘要
目的探讨血清C反应蛋白(CRP)与时间关系对急性一氧化碳中毒(ACOP)患者的临床意义。方法回顾性分析2014年11月至2017年3月河北工程大学附属医院急诊科收治的90例急性一氧化碳中毒患者的临床资料,根据入院时中毒的程度分为轻度中毒组(30例)、中度中毒组(30例)、重度中毒组(30例),以同期同院门诊健康体检者30例为对照组。于入院后12 h、24 h、48 h、72 h、96 h化验血清CRP,比较不同时间段各组间CRP水平的差异。对经治疗后的一氧化碳中毒患者随诊2个月,根据是否出现迟发型脑病分为脑病组和无脑病组,比较不同组别间CRP水平的差异及中毒程度与迟发型脑病发病的相关性。结果入院第12 h,轻度中毒组为(3.81±0.28)mg/L、中度中毒组CRP为(13.26±1.85)mg/L、重度中毒组为(26.70±1.70)mg/L,对照组为(3.35±0.91)mg/L,组间比较差异均有统计学意义(P<0.05)。随着治疗时间延长,一氧化碳中毒患者CRP水平呈上升趋势,但轻、中度组CRP水平于24 h达到最高值,之后逐渐下降,重度中毒组CRP在48 h达到最高,48 h后呈缓慢下降趋势。重度中毒组入院后24h、48 h、72 h以及96 h血清CRP水平与轻度中毒组、中度中毒组比较,差异均有显著统计学意义(P<0.01)。治疗后对一氧化碳中毒患者出院随诊2个月,按是否出现迟发性脑病分为脑病组(30例)和无脑病组(60例),且脑病组均为中度和重度中毒患者。脑病组患者入院后12 h、24 h、48 h、72 h以及96 h的血清CRP水平与无脑病组比较,差异均具有显著统计学意义(P<0.01)。结论早期CRP检测可作为诊断一氧化碳中毒患者中毒程度和判断预后的重要指标。
Objective To investigate the clinical significance of the relationship between serum C reactive protein（CRP） and time in patients with acute carbon monoxide poisoning（ACOP）.Methods A retrospective analysis was performed on 90 cases of ACOP patients,who admitted to Department of Emergency of our hospital from November2014 to March 2017.According to the degree of poisoning on admission,these patients were divided into three groups：mild poisoning group,moderate poisoning group,severe poisoning group,with 30 cases in each group.Meantime,30 cases of health examination in the same hospital were taken as the control group.The serum CRP at 12,24,48,72,96 hours after admission was tested and compared.The patients with ACOP were followed up for 2 months after treatment.According to whether the appearance of delayed encephalopathy,the patients were divided into encephalopathy group and encephalopathy group.The correlation between the difference of CRP value between different groups and the degree of poisoning with the pathogenesis of delayed encephalopathy were analyzed.Results Twelve hours after the admission,the CRP levels of the control group,Mild poisoning group,moderate poisoning group,severe poisoning group were respectively（3.35±0.91） mg/L,（3.81±0.28） mg/L,（13.26±1.85） mg/L,（26.70±1.70） mg/L,and the differences between the three groups were statistically significant（P0.05）.With the prolongation of treatment time,the level of CRP in different carbon monoxide poisoning groups showed an increasing trend.The CRP level in the mild and moderate poisoning group reached the highest value at 24 h,and then decreased gradually.The CRP level in the severe poisoning group reached the highest value at48 h,and then decreased gradually.In the severe poisoning group,the serum CRP levels at 24 h,48 h,72 h and 96 h after admission were significantly different from those in the mild poisoning group and moderate poisoning group（P0.01）.After the treatment,the patients with ACOP were followed up for 2
出处
《海南医学》
CAS
2017年第24期4032-4035,共4页
Hainan Medical Journal
基金
河北省邯郸市科技局科研项目(编号:1449301088-7)
关键词
C反应蛋白
中毒程度
急性一氧化碳中毒
预后
C-reactive protein （CRP）
Posioning degree
Acute carbon monoxide poisoning （ACOP）
Prognosis
