摘要
菲啶/苯骈菲啶衍生物是一类含氮杂环化合物,由于在抗肿瘤、抗血管生成、抗血小板、抗病毒和抗真菌等方面均表现出较好的生物活性而备受关注。本文按其主要作用靶点,如拓扑异构酶、微管蛋白、端粒酶等,综述了近年来菲啶/苯骈菲啶衍生物在抗肿瘤方面的研究进展。希望通过总结构效关系,探寻发现靶向性、高选择性、高效低毒的菲啶类抗肿瘤药物的结构规律,为进一步研究开发抗肿瘤药物提供帮助。
Phenanthridine/benzo [c] phenanthridine are a series of heterocyclic compounds, which have received much attention and are used as antitumor, anti-angiogenesis, antiplatelet, antiviral and anti-fungal agents. This review focused on the recent progress on the antiturnor activity of natural and synthetic phenanthridine/benzo Eel -phenanthridines derivatives, including their inhibition on topoisomerase I /II, tubulin, telomerase, etc. Phenanthridines/benzo [el phenanthridines with high selectivity, targeting, high efficiency and low toxicity will be found through structure-activity relationship study, which will provide new sights for investigation of anti-tumor drugs.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2018年第3期273-283,共11页
Chinese Journal of Pharmaceuticals
