摘要
目的探讨替罗非班联合瑞舒伐他汀治疗不同年龄不稳定型心绞痛的临床效果。方法选取2016年2月~2017年11月我院收治的300例不稳定型心绞痛患者,按照年龄的不同分为青年组(20~44岁)、中年组(45~59岁)、老年组(≥60岁),各100例。三组均采用替罗非班联合瑞舒伐他汀治疗,比较三组受试者治疗后的临床效果、心电图变化、心脏彩超检查结果以及不良心脏事件发生情况。结果青年组、中年组、老年组受试者治疗后的临床总有效率分别为93.00%、91.00%、88.00%,差异无统计学意义(P>0.05)。心电图检测结果显示,三组受试者治疗后的ST段下移幅度均显著低于治疗前(P<0.05),三组治疗后的ST段下移幅度比较,差异无统计学意义(P>0.05)。心脏彩超检查结果显示,三组受试者治疗后的LVDd、LVST与治疗前比较,差异无统计学意义(P>0.05)。三组受试者治疗后的心绞痛发作时间、发作次数比较,差异无统计学意义(P>0.05)。治疗后,青年组无受试者发生心肌梗死,中年组、老年组受试者心肌梗死发病率分别为1%和11%,三组间差异有统计学意义(P<0.05)。结论替罗非班联合瑞舒伐他汀治疗不同年龄不稳定型心绞痛均具有较好的临床效果,但老年人群治疗后不良心脏事件发生率明显高于青年及中年人群。
Objective To investigate the clinical effect of Tirofiban combined with Rosuvastatin in the treatment of dif- ferent ages patients with unstable angina pectoris.nethods 300 patients with unstable angina pectoris treated in our hospital from February 2016 to November 2017 were selected.According to the different age,all patients were divided into the the youth group （20-44 years old）,the middle-aged group （45-59 years old） and the elderly group （over 60 years）,100 cases in each group.The three groups were treated with Tirofiban combined with Rosuvastatin.The clinical effects,ECG changes,echocardiography and adverse cardiac events in the three groups after treatment were compared. Results The total effective rate in the youth group,the middle-aged group and the elderly group was 93%,91% and 88% respectively,and there was no significant difference （P〉0.05）.Electrocardiogram detection results showed that the decline amplitude degree of ST segment in the three groups was significantly lower than that before treatment （P〈0.05）. There was no significant difference in the decline amplitude degree of ST segment between the three groups after treatment （P〉0.05）.The results of color Doppler echocardiography showed that there was no significant difference in the LVDd and LVST between the three groups after treatment （P〉0.05）.There was no significant difference in the attack time and frequency of episodes of angina pectoris after treatment in the three groups （P〉0.05）.After treatment,there was no myocardial infarction in the young group.The incidence rate of myocardial infarction in the middle-aged group and the elderly group was 1% and 11%,respectively,there was significant difference between the three groups （P〈0.05）. Conclusion Tirofiban combined with Rosuvastatin in the treatment of unstable angina pectoris of different ages has better clinical effect,but the incidence rate of adverse cardiac events in elderly patients is significantly higher than that in young and middle-ag
出处
《中国当代医药》
2018年第4期16-19,24,共5页
China Modern Medicine
基金
广东省揭阳市卫生和计划生育局医学科学技术研究立项项目(揭市卫[2016]67号)
