摘要
银屑病是一种免疫介导的慢性炎症性皮肤病,环孢素A作为一种高选择性免疫抑制剂,以抑制白介素-2为主的促炎症细胞因子生成为机理,从而发挥对银屑病的治疗作用。目前无论是环孢素A单一药物的短程、长程和间断维持疗法,还是与其他治疗银屑病的系统性药物、生物制剂及紫外线光疗联合应用,均在银屑病皮损控制及疗效维持等方面有较为明确的治疗作用。本文将现阶段临床上环孢素A在银屑病治疗中的应用及相关药物特性等问题作一总结,为环孢素A临床用于银屑病治疗提供参考。
Psoriasis is a chronic inflammatory immuno-mediated disease,while cyclosporine A acts as a high selective immuno-suppressor,which aims at reducing the expression of pro-inflammatory cytokines like IL-2 to complete the task of treating the psoriasis. Nowadays,not only the short-term,long-term or intermittment monotherapy of cyclosporine A,but also the combination therapy of cyclosporine A with other systemic drugs,biological agents or ultraviolet phototherapy have therapeutic effect on the skin lesion control and curative effect maintaining. The purpose of this article is to summarize the therapeutic use of cyclosporine A in psoriasis treatment and the pharmacological characters of cyclosporine A,and so as to provide a reference for psoriasis treatment.
出处
《皮肤科学通报》
2018年第1期8-17,共10页
Dermatology Bulletin
关键词
环孢素A
银屑病
Cyclosporine A（CsA）
Psoriasis
