摘要
酒精性肝损伤是由于长期大量饮酒导致的肝脏疾病。初期通常表现为脂肪肝,进而可发展成酒精性肝炎、肝纤维化和肝硬化。其主要临床特征是恶心、呕吐、黄疸,可有肝脏肿大和压痛;可并发肝功能衰竭和上消化道出血等。现酒精性肝损伤动物模型为病理模型,以西医指标为主。基于对酒精性肝损伤中西医临床病症特点分析及对现有动物模型大量实验研究,形成如下酒精性肝损伤动物模型制备规范(草案)。
Alcoholic liver injury is a liver disease caused by long-term heavy drinking. Fatty liver is usually seen in the early stage, and then can develop into alcoholic hepatitis, liver fibrosis and cirrhosis. The main clinical features are nausea, vomiting, jaundice, liver swelling and tenderness, complicated with liver failure and upper gastrointestinal bleeding. The animal model of alcoholic liver injury is a pathological model with western medicine as the main index. Based on the analysis of the clinical characteristics of alcoholic liver injury in TCM and western medicine and a large number of experimental studies on the existing animal models, the following guidelines for the preparation of alcoholic liver injury animal models were established.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2018年第3期1000-1003,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家“十一五”支撑计划(No.2008BAI53B09)
国家中医药管理局中医药标准化专项(No.2017-149-11)
关键词
酒精性肝损伤
动物模型
规范
Alcoholic liver injury
Animal model
Standard
