摘要
目的探讨阴道后穹隆分泌物胎儿纤连蛋白(fFN)浓度对伴先兆早产症状双胎早产孕妇2周内分娩的预测价值。方法选取上海交通大学医学院附属新华医院于2015年3月至2017年2月期间收治的64例具有先兆早产的双胎孕妇,对所有入选孕妇的阴道后穹窿分泌物fFN浓度进行检测,并且评价分析fFN浓度对各孕妇2周内进行分娩的阴性预测值、阳性预测值,以及特异性和敏感性等。结果 fFN阴性组孕妇有41例,fFN阳性组孕妇23例,其中fFN阴性组孕妇的早产孕周为34.22±1.92周,显著晚于fFN阳性组孕妇(33.81±1.77周),差异有统计学意义(t=2.263,P<0.05)。fFN阳性组孕妇<37周分娩率为39.13%,显著高于fFN阴性组孕妇的7.32%,差异有统计学意义(χ~2=6.537,P<0.05)。阴道后穹窿分泌物fFN对伴先兆早产症状双胎早产孕妇1周内分娩、2周内分娩及<37周分娩价值中,1周内分娩的阴性预测值和灵敏度最高,均为100%;<37周分娩的特异度最高,为73.08%。结论阴道后穹隆分泌物fFN浓度对伴先兆早产症状双胎早产孕妇2周内的分娩具有较好的预测价值,其中阴道后穹隆分泌物fFN阴性的孕妇早产率较低。
Objective To investigate the predictive value of fetalfibronectin（fFN）concentration in posterior fornix secretion for delivery within 2 weeks in twin pregnant women with threatened preterm birth.Methods Sixty-four twin pregnant women with threatened preterm birth admitted in Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine from March2015 to February 2017 were selected.Concentration of fFN in posterior fornix secretion was detected in all pregnant women selected.Negative predictive value,positive predictive value,specificity and sensitivity of fFN concentration in predicting delivery within 2 weeks were assessed.Results There were 41 cases in fFN negative group and 23 cases in fFN positive group.Premature delivery happened at 34.22±1.92 weeks of pregnancy in fFN negative group,which was significantly later than premature delivery at 33.81±1.77 weeks of pregnancy in fFN positive group,and difference was statistically significant（t=2.263,P〈0.05）.Delivery rate at37 weeks of pregnancy in fFN positive group was 39.13%,which was significantly higher than that of 7.32% in fFN negative group,and difference had statistical significance（χ~2=6.537,P〈0.05）.For value of posterior fornix secretion fFN in predicting delivery within 1 week and 2 weeks or delivery at37 weeks in twin pregnant women with threatened premature birth,its negative predictive value and sensitivity in predicting delivery within 1 week were highest,which were both 100%and specificity in predicting delivery at37 weeks was highest,which was 73.08%.Conclusion Concentration of fFN in posterior fornix secretion has good predictive value for delivery within 2 weeks in twin pregnant women with threatened premature birth.Pregnant women with negative posterior fornix secretion fFN have lower premature birth rate.
出处
《中国妇幼健康研究》
2017年第12期1582-1584,共3页
Chinese Journal of Woman and Child Health Research
关键词
先兆早产
双胎
阴道后穹窿
预测价值
孕妇
threatened premature labor
twin pregnancy
posterior fornix
predictive value
pregnant women
