摘要
多囊卵巢综合征(PCOS)是育龄期妇女最常见的生殖内分泌疾病,以生殖和代谢异常为主要特征。临床上PCOS患者出现的高雄激素血症、胰岛素抵抗(IR)及低黄体酮均可引起机体免疫系统异常活化,导致机体免疫功能紊乱,进而加剧生殖和代谢异常。本文综述了近年来免疫与PCOS关系的研究进展,从免疫学角度探讨PCOS的发病机理。
Polycystic ovary syndrome（PCOS） is the most common reproductive endocrinopathy affecting females during reproductive age. Reproductive and metabolic disorder are the main features of the syndrome. Clinically,hyperandrogenism, insulin resistance and low level of progesterone in PCOS can cause over-stimulation of immune system that results in immune disorders. Perturbations in immune system further aggravate the reproductive and metabolic syndrome. Here, we reviewed the current understanding of immune-PCOS interactions and expected to explore the pathogenesis of PCOS.
出处
《中华生殖与避孕杂志》
CAS
CSCD
北大核心
2017年第12期1028-1030,共3页
Chinese Journal of Reproduction and Contraception
