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培美曲塞治疗肺腺癌的癌胚蛋白疗效观察

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摘要 目的:观察培美曲塞治疗肺腺癌的癌胚蛋白的临床疗效.方法:采用随机数字表法,对我院2012∽2016年收治的60例肺腺癌患者的临床资料进行随机查验分析,依照治疗方法和策略的不同,分为对照组(n=30例)和观察组(n=30例),对照组应用治疗肺腺癌的常规化疗方法,观察组在此基础上增加培美曲塞联合治疗,临床观察和比对两组患者的癌胚蛋白信分子表达效果.结果:对照组治疗总有效率70.00%(21/30)明显低于观察组患者临床治疗总有效率93.33%(28/30),两组数据差异具有统计学意义(P〈0.05);治疗后,肺腺癌胚蛋白分子抑制水平明显上升--GFR(表皮生长因子受体)、DEC1(分化型胚胎软骨表达基因1)、HIF1α(低氧诱导因子1α)、STAT3(信号转导及转录激活因子)及VEGF(血管内皮生长因子),两组数据差异具有统计学意义(P〈0.05).结论:培美曲塞治疗肺腺癌的癌胚蛋白的临床疗效确切,治疗后抑制GFR(表皮生长因子受体)、DEC1(分化型胚胎软骨表达基因1)、HIF1α(低氧诱导因子1α)、STAT3(信号转导及转录激活因子)及VEGF(血管内皮生长因子)的水平和变化程度较高,具有联合化疗的辅助治疗功效,值得临床推广.
作者 刘冬梅
出处 《三峡大学学报(自然科学版)》 CAS 2017年第A02期59-60,共2页 Journal of China Three Gorges University:Natural Sciences
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