摘要
目的:观察泻火降逆汤治疗肝胃郁热型胃食管反流病(GERD)的临床疗效及对胃肠激素的影响。方法:将100例患者采用随机法分为观察组和对照组各50例,对照组给予奥美拉唑肠溶胶囊和枸橼酸莫沙比利片口服,观察组在常规口服奥美拉唑肠溶胶囊的基础上,给予中药泻火降逆汤辨证加减治疗,2组均连续治疗8周,观察2组临床疗效、治疗前后证候积分和血清P物质(SP)、胆囊收缩素(CCK)的变化情况。结果:总有效率观察组为92.00%,对照组为64.00%,2组比较差异有统计学意义(P<0.05)。证候积分2组治疗后各时间点比较,差异均有统计学意义(P<0.05)。烧心、胸痛、反酸、腹胀、嗳气等症状的痊愈率2组比较,差异有统计学意义(P<0.05)。血清SP及CCK治疗前后2组组内比较,差异有统计学意义(P<0.05),治疗后组间比较,差异也有统计学意义(P<0.05)。结论:泻火降逆汤能较好地改善肝胃郁热证GERD患者的主要症状、体征,使SP、CCK等胃肠激素分泌趋于正常,且临床疗效显著。
Objective: To observe clinical effects of Xie Huo Jiang Ni decoction in treating gastroesophageal reflux disease(GERD) of liver-stomach stagnant-heat pattern and its influence on gastrointestinal hormone.Methods: All 100 patients were allocated to the observation group and the control group by using randomized method, 50 cases each group, the control group took omeprazole enteric-coated capsules and mosapride citrate tablets orally, and the observation group were treated with modified Xie Huo Jiang Ni decoction by syndrome differentiation on the foundation of oral administration of omeprazole enteric-coated capsules, both groups were treated for eight weeks consecutively, clinical effects, syndrome scales and the changes of serum P substances and cholecystokinin(CCK) in both groups were observed. Results: Total effective rate of the observation group was92.00%, higher than 64.00% of the control group, and the difference had statistical meaning(P <0.05). The difference was statistically significant in the comparisons of syndrome scales between both groups after treating at different times(P <0.05). The difference showed statistical meaning in the comparisons of the cure rates of the symptoms including heartburn, chest pain, sour regurgitation, abdominal distension, belching and others(P<0.05).The difference was statistically significant in the comparisons of the levels of SP and CCK before and after treating within two groups(P <0.05), and there was a significant difference in the comparisons between both groups after treating(P<0.05). Conclusion: Xie Huo Jiang Ni decoction could improve main symptoms of GERD patients of liver-stomach stagnant heat pattern, make the secretion of SP and CCK normal and obtain notable effects.
出处
《西部中医药》
2018年第2期82-84,共3页
Western Journal of Traditional Chinese Medicine
基金
上海市浦东新区传统型中医临床示范学科建设资助项目(编号PDZYXK-3-2013008)
周浦医院重点学科建设资助项目(编号ZP-XK-2015B-5)
关键词
胃食管反流病
肝胃郁热证
泻火降逆汤
胃肠激素
gastroesophageal reflux disease
liver-stomach stagnant heat pattern
XieHuo JiangNi decoction
gastrointestinal hormone
