摘要
目的探讨氯吡格雷联合阿司匹林对老年短暂性脑缺血发作的临床效果。方法回顾2016年1月—2017年6月84例老年短暂性脑缺血发作患者并分组。对照组采用阿司匹林进行治疗,联合组采用氯吡格雷联合阿司匹林治疗。比较两组老年短暂性脑缺血发作转归率;药物安全特性;干预前后患者神经功能缺损积分、红细胞聚集指数和压积。结果联合组老年短暂性脑缺血发作转归率高于对照组,P<0.05;联合组药物安全性和对照组对比,差异无统计学意义,P>0.05;干预前两组神经功能缺损积分、红细胞聚集指数和压积相近,P>0.05;干预后联合组神经功能缺损积分、红细胞聚集指数和压积低于对照组,P<0.05。结论氯吡格雷联合阿司匹林对老年短暂性脑缺血发作的效果肯定,可改善血液流变学和恢复神经功能,安全性高。
Objective To investigate the clinical effect of clopidogrel combined with aspirin on transient ischemic attack in the elderly. Methods 84 cases of transient ischemic attack in the aged from January 2016 to June 2017 were reviewed and divided into groups. The control group was treated with aspirin, and the combined group was treated with clopidogrel and aspirin. The outcome rates of transient ischemic attack in two groups were compared, drug safety characteristics, neurological deficit scores, erythrocyte aggregation index and hematocrit before and after intervention. Results The rate of transient ischemic attack in the aged group was higher than that of the control group, P 〈 0.05. The drug safety of the combined group was no significant difference between the control group and the control group, P 〉 0.05. The scores of nerve function defect, red cell aggregation index and hematocrit were similar in the two groups before intervention, P 〉 0.05. The score of neural function defect, erythrocyte aggregation index and hematocrit in the combined group were lower than that of the control group, P 〈 0.05. Conclusion The effect of clopidogrel combined with aspirin on transient ischemic attack in the elderly can improve the blood rheology and restore the nerve function with high safety.
出处
《中国继续医学教育》
2018年第6期123-124,共2页
China Continuing Medical Education
关键词
氯吡格雷
阿司匹林
老年短暂性脑缺血
临床效果
clopidogrel
aspirin
transient ischemic stroke in the elderly
clinical effect
