摘要
目的探讨稳定型心绞痛患者接受硫酸氢氯吡格雷联合阿司匹林治疗的价值。方法选取2015年3月10日~2016年8月30日我院收治的200例稳定型心绞痛患者作为研究对象,根据患者治疗方案不同分为两组,每组各100例。对照组患者在阿托伐他汀和倍他乐克等常规治疗的基础上接受阿司匹林治疗,实验组患者则同时接受阿司匹林和硫酸氢氯吡格雷治疗。比较两组患者的临床效果、不良反应发生情况、治疗前后心绞痛发作次数、发作持续时间以及纤维蛋白原水平。结果实验组患者的治疗总有效率(94.00%)明显高于对照组(84.00%),差异有统计学意义(P<0.05)。治疗后,两组患者的心绞痛发作次数少于本组治疗前,发作持续时间短于本组治疗前,同时实验组患者的心绞痛发作次数少于对照组,发作持续时间短于对照组,纤维蛋白原水平低于对照组,差异均有统计学意义(P<0.05)。两组患者的不良反应发生率比较,差异无统计学意义(P>0.05)。结论稳定型心绞痛患者接受硫酸氢氯吡格雷联合阿司匹林治疗,可以提高疗效,改善患者的心功能,意义重大,值得临床推广应用。
Objective To explore the value of the treatment of Chloropidogrel Sulfate combined Aspirin in patients with stable angina peetoris.Methods 200 patients with stable angina treated in our hospital from March 10,2015 to August 30,2016 were selected as subjects and were devided into two groups according to the patient treatment plan,100 cases in each group.Patients in the control group received Aspirin treatment on the basis of routine treatment such as Atorvastatin and Betalogram,while patients in the experimental group were treated with Aspirin and Chloropidogrel Sulfate. The clinical efficacy,the occurrence of adverse reactions,the number of angina peetoris onset,the duration of the attack and fibrinogen level were compared.Results The total effective treatment rate in the experimental group （94.00%） was significantly higher than that in the control group （84.00%）,and the difference was statistically significant （P〈0.05）.After treatment,the number of angina pectoris onset of patients in the two groups were less than before treatment,the duration of the attack were shorter than before treatment,at the same time,the number of angina peetoris onset of patients in the experimental was less than that in the control group,the duration of the attack was shorter than that in the control group,the fibrinogen levels was lower than that in the control group,the differences were statistically significant （P〈 0.05）.There was no statistically significant difference of the occurrence of adverse reactions between the two groups （P〉 0.05）.Conclusion It is significant that patients with stable angina peetoris should be treated with Chloropidogrel Sulfate combined with Aspirin to improve the curative effect and the cardiac function of patients.It is of great significance and is worthy of clinical application.
出处
《中国当代医药》
2018年第3期108-110,共3页
China Modern Medicine
