摘要
目的观察2型糖尿病合并冠心病患者血清膜联蛋白A1(AnxA1)及γ-谷氨酰转肽酶(GGT)的水平变化,探讨这两项指标与冠状动脉血管狭窄程度的相关性。方法收集2015年6月至2016年12月在河南理工大学第一附属医院内分泌科及心内科接受冠状动脉造影检查并诊断为冠心病的2型糖尿病患者186例作为观察组,根据冠状动脉狭窄的Gensini评分结果将入选患者分为:低分组(n=89)和高分组(n=97),同时选取同期造影结果正常的2型糖尿病患者96例作为对照组。分析AnxA1及GGT水平的变化及其与Gensini评分的关系。结果观察组的AnxA1及GGT明显高于对照组,且狭窄程度重的高分组患者AnxA1及GGT水平明显高于低分组(P<0.05),差异均有统计学意义(P<0.05);AnxA1、GGT水平与冠状动脉狭窄程度呈正相关,且为高冠脉Gensini积分的独立危险因素(P<0.05)。结论 AnxA1及GGT水平与2型糖尿病合并冠心病患者冠脉狭窄程度具有正相关性并对病情严重程度具有提示意义。
Objective To analyze the relationship observe between serum Annexin A1（AnxA1）and gamma-glutamyl transferase（GGT）levels and coronary artery stenosis degree in patients with type 2 diabetes mellitus complicated by coronary heart disease.Methods According to the results of coronary angiography,patients（n=186）with type 2 diabetes mellitus complicated by coronary heart disease from June 2015 to December 2016 in our hospital Department of Endocrinology and Cardiology were studied. All patients were divided into low score group（n=89）and high score group（n=97）on the basis of Gensini scores of coronary stenosis;patients（n=96）with normal coronary arteriograms of type 2 diabetes mellitus were selected as a control. The relationship between AnxA1,GGT and Gensini scores of coronary stenosis were analyzed. Results In type 2 diabetes mellitus complicated by coronary heart disease patients group,the levels of AnxA1 and GGT were significantly higher than those of the control group（P0.05）. And in the high score group,the levels of AnxA1 and GGT were significantly higher than those in the low score group（P0.05）. The levels of AnxA1 and GGT were positively correlated with the degree of coronary artery stenosis,and the independent risk factors for Gensini score of high coronary artery（P0.05）.Conclusion AnxA1 and GGT levels were positively correlated with the degree of coronary artery stenosis.
出处
《热带医学杂志》
CAS
2018年第1期54-57,共4页
Journal of Tropical Medicine
关键词
血清膜联蛋白A1
Γ-谷氨酰转肽酶
2型糖尿病
冠心病
冠脉狭窄
Serum Annexin A1
Gamma-glutamyl transferase
Type 2 diabetes mellitus
Coronary heart disease
Coronaryartery stenosis
