摘要
生物体所处的内外环境因素均可以引起DNA损伤,如果不能及时正确的修复,将会导致基因组的不稳定性,威胁细胞的生存。染色质化的DNA在复杂的基因组环境中为了维持其结构和功能的稳定性,必须准确的对损伤性信号做出及时合理的应答。在DNA损伤的条件下,遗传信息和表观遗传信息的保真性维持需要损伤修复机器和染色质动态变化协同调节来保证。当特定DNA损伤修复通路中关键蛋白质发生突变时,会导致一系列的遗传疾病或肿瘤的发生,充分显示DNA损伤所造成危害的严重性和修复机制的重要性。本文将对DNA损伤修复的分子机制做一综述。
Both internal and external environmental factors can cause DNA damage in living organisms, and ifsuch damage is not repaired timely, it may lead to genomic instability and threaten cell survival. In order to maintainstructural and functional stability in the complex genomic environment, chromatinized DNA must respond accuratelyand reasonably to damage signals. In the case of DNA damage, the fidelity of genetic and epigenetic informationshould be maintained by synergistic regulation of damage repair machine and dynamic change of chromatin. Muta-tions of key proteins in specific DNA damage repair pathways may lead to a series of genetic diseases or tumors,which indicates the seriousness of harm caused by DNA damage and the importance of repair mechanism. This arti-cle reviews the molecular mechanism of DNA damage repair.
出处
《西南医科大学学报》
2018年第1期94-96,共3页
Journal of Southwest Medical University
基金
国家自然基金优秀青年基金项目(81722036)
国家自然基金面上项目(31671474
81272284)
