摘要
目的:探讨急性心肌梗死患者血清心肌肌钙蛋白(cTnⅠ)、肌红蛋白(Myo)、纤维蛋白降解产物(FDP)、D-二聚体(DD)检测的临床意义。方法:选取本院收治的32例急性心肌梗死患者为研究对象(AMI组),同时选取30例健康者为对照组,应用免疫荧光法、凝固法分别检测cTnI、Myo和FDP、DD,并进行比较分析。结果:经检测,AMI组cTnI、Myo、FDP、DD含量分别为30.58(0.01~51.34)ng/ml、121.39(32.29~136.45)μg/L、6.83(4.32~8.34)μg/ml、2.66(0.52~5.78)μg/ml,对照组分别为0(0~0.01)ng/ml、21.48(15.47~54.68)μg/L、2.43(1.37~5.48)μg/ml、0.16(0.02~1.18)μg/ml,两组cTnI、Myo、FDP、DD含量比较差异有统计学意义(P<0.01);cTnI、Myo、FDP、DD 4项指标检测的阳性率分别为84.38%、90.63%、78.13%、81.25%,经ROC曲线分析,当其分别取截断值cTnI>10.72ng/ml、Myo>56.27μg/L、FDP>5.50μg/ml、DD>0.73μg/ml时,曲线下面积最大,分别为0.958、0.974、0.939、0.972,youden指数分别为0.844、0.739、0.648、0.806。结论:血cTnI、Myo和FDP及DD在AMI患者中均有明显升高,其检测对诊断急性心肌梗死具有重要的临床应用价值,在AMI患者的临床诊断和治疗中可推广应用。
Objective：To investigate the clinical significance of serum cardiac troponin（cTnⅠ）,myoglobin（myo）,fibrin degradation products（FDP）and D-dimer（DD）in patients with acute myocardial infarction.Methods：32 patients with acute myocardial infarction were selected as the study subjects（AMI group）,and 30 healthy subjects were selected as the control group.Immuno-fluorescence method and coagulation method were used to detect cTnI,Myo and FDP,DD,respectively.And then the test results were compared and analyzed.Results：The levels of cTnI,Myo,FDP and DD in AMI group were 30.58（0.01-51.34）ng/ml,121.39（32.29-136.45）μg/L,6.83（4.32-8.34）μg/ml,2.66（0.52-5.78）μg/ml,with 0（0-0.01）ng/ml,21.48（15.47-54.68）μg/L,2.43（1.37-5.48）μg/ml,0.16（0.02-1.18）μg/ml in the control group,and significant differences were found in cTnI,Myo,FDP,DD between AMI group and control group（P〈0.01）.The positive rates of cTnI,Myo,FDP,DD were 84.38%,90.63%,78.13%and 81.25%,respectively.Analysis by ROC curve,the cutoff values of cTnI,Myo,FDP,DD were 10.72 ng/ml,56.27μg/L,5.50μg/ml,0.73μg/ml,and the largest area under the curve were 0.958,0.974,0.939,0.972,respectively,the youden index were 0.844,0.739,0.648,0.806,respectively.Conclusion：The contents of serum cTnI,Myo and FDP and DD increase significantly in AMI patients,and the detection of them are of important clinical value in the diagnosis of AMI,the application of them can be promoted in the clinical diagnosis and treatment in AMI patients.
出处
《医学理论与实践》
2018年第3期326-328,共3页
The Journal of Medical Theory and Practice
