摘要
为了系统地反映内源性甲醛能与生物体内的一些重要分子,如蛋白质、核酸及神经递质等发生生理生化反应,及其对结构与功能的影响,综述了人体、动植物及微生物内源性甲醛在生物体内的产生过程、产生毒性的机制及代谢途径等方面的具体的研究成果。多数研究采用甲醛捕获剂的方法消除过量的内源性甲醛,但加入的甲醛捕获剂是否干扰机体正常的甲醛生化反应途径值得考虑。因此,采用代谢调控策略对生物机体的甲醛平衡提供指导,对于全面理解和降低内源性甲醛对生命机体的影响具有重要意义。
Aiming at the endogenous formaldehydes reacting with important molecules in organism,such asprotein, nucleic acids and neurotransmitters, and affecting their structures and functions, we havesystematically reviewed the research progress of endogenous formaldehyde production, the mechanism oftoxicity and metabolic pathways in organisms. Recently,the most commonly used method for eliminating excessendogenous formaldehyde is to add the capture agents,however,whether the formaldehyde capture agentinterferes the normal formaldehyde biochemical reaction is worth considering. Therefore,the paper proposes themetabolic regulation strategies to achieve formaldehyde balance of organisms,which is of great significance forcomprehensively understanding and reducing the effects of endogenous formaldehyde on organisms.
出处
《武汉工程大学学报》
CAS
2018年第1期8-16,27,共10页
Journal of Wuhan Institute of Technology
关键词
内源性甲醛
生物机体
毒性机制
代谢途径
endogenous tormaldehyde
organism
mechanisms of toxicity
metabolic pathway
