摘要
目的探讨T1-T3期乳腺癌超声光散射参数分布差异及临床特征。方法选取447例乳腺癌患者（共455个癌灶），术前1～2 d超声光散射获得病灶超声最大径、最大血红蛋白浓度（total hemoglobin concentration，THC），记录患者年龄、体重指数、病灶距皮肤和乳头的距离、淋巴结有否转移。参考美国癌症联合委员会第七版癌症分期对病灶按照大小分为T1期（病灶≤2 cm）、T2期（2 cm〈病灶≤5 cm）、T3期（病灶〉5 cm）3组。结果455个乳腺癌灶中，T1期148个，T2期251个，T3期56个，患者年龄、病灶大小、病灶THC及病灶距乳头的距离在乳腺癌T1-T3期中差异均有统计学意义（P＝0.000）。T3期THC[（233.1±54.0）μmol/L]和T2期THC[（221.0±56.0）μmol/L]均显著大于T1期[（181.6±70.4）μmol/L]（P＝0.000）。随着T分期增加即病灶增大，发病年龄逐渐减小，病灶距乳头的距离逐渐减小，病灶THC增加。患者的体重指数及病灶距皮肤的距离在乳腺癌不同T分期中差异均无统计学意义（P〉0.05）。淋巴结转移率在乳腺癌T1-T3期中分布差异有统计学意义（P＝0.000），随着T分期增加，淋巴结转移的比率依次增加，即T1期26.4%，T2期49.8%，T3期55.4%。结论随着乳腺癌T分期增加，病灶THC增加，患者年轻化及淋巴结转移率增加。
ObjectiveTo explore the ultrasound-guided diffuse optical tomography（DOT） distribution difference and clinical characteristics of T1-T3 breast carcinoma.MethodsFour hundred and forty-seven breast cancer patients with 455 breast lesions were enrolled. The lesion maximal diameter and total hemoglobin concentration（THC） were obtained by ultrasound-guided DOT before breast surgery biopsy. The patients age, body mass index（BMI）, and the distances from lesion to skin and nipple were measured, lymph node status were also assessed. According to the 7th Edition of the AJCC Cancer Staging, all tumors were divided into T1（≤2 cm）, T2（2 cm〈lesion≤5 cm）, and T3（〉5 cm） three groups according to maximum diameter on ultrasound.ResultsOut of 455 breast cancer lesions, 148 lesions were stage T1, 251 lesions were stage T2, 56 lesions were T3. The age, lesion size, lesion THC and the distances between lesions and nipples of breast cancer patients were found that there were significant differences among T1, T2 and T3（all P=0.000）. With T stages increasing, the age of breast cancers patients decreased, the distance between lesions and nipples decreased, the THC increased. THC of breast cancer T2[（221.0±56.0）μmol/L] and T3[（233.1±54.0）μmol/L] were significant higher than that of T1 [（181.6±70.4）μmol/L]（all P=0.000）. There were all no significant difference for BMI and the distancefrom lesion to skin among different stages T（P〉0.05）. With T stages increasing, the ratio of lymph node metastasis increased（T1 26.4%, T2 49.8%, T3 55.4%; P=0.000）.ConclusionsWith breast cancer T stages increasing, THC increases, the age of the patients decreases, lymph node metastasis rate increases.
出处
《中华超声影像学杂志》
CSCD
北大核心
2018年第1期31-35,共5页
Chinese Journal of Ultrasonography
基金
国家自然科学基金面上项目（81371575）
国家重大科研仪器研制项目（81627804）
上海市卫生和计划生育委员会（201440424）
复旦大学附属肿瘤医院影像医学专项基金（YX201401）
关键词
超声检查
乳腺肿瘤
光散射断层成像
最大血红蛋白浓度
Ultrasonography
Breast neoplasms
Diffuse optical tomography
Total hemoglobinconcentration
