摘要
目的研究碱性成纤维生长因子(b FGF)及其受体、血管内皮因子(VEGF)及其受体在宫颈上皮内瘤变III级(CIN III)和宫颈鳞状细胞癌中的表达及临床意义。方法应用微波修复免疫组化S-P法检测68例宫颈癌患者中b FGF及其受体、VEGF及其受体的表达情况。结果宫颈鳞状细胞癌组b FGF及其受体、VEGF及其受体与宫颈CIN III组表达差异有统计学意义(P<0.01)。结论 b FGF及其受体、VEGF及其受体与宫颈癌是否浸润、复发及浸润能力密切相关。
[Objective] To investigate the expression levels and clinical significance of basic fibroblast growth factor （bFGF）, vascular endothelial growth factor （VEGF） and their receptors in cervical intraepithelial neoplasia III （C1N III） and squamous cell carcinoma of uterine cervix. [Methods] The expression products of bFGF, VEGF and their receptors in tissues from 68 patients with carcinoma of uterine cervix were assessed by microwave retrieved immunohistochemical （streptavidin-perosidase, SP） technique. [Results] bFGF, VEGF and their receptors showed significant differences between carcinoma of uterine cervix and CIN III （P 〈0.01）. [Conclusion] bFGF, VEGF and their receptors are closely related to infiltration and relapse in carcinoma of uterine cervix.
出处
《中国医学工程》
2017年第12期1-4,共4页
China Medical Engineering
关键词
碱性成纤维生长因子
血管内皮因子
受体
宫颈癌
复发
浸润性
basic fibroblast growth factor
vascular endothelial growth factor
receptor
carcinoma of uterine cervix
relapse
infiltration
